HER2-positive advanced breast cancer
Clinical trials for HER2-positive advanced breast cancer explained in plain language.
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Can a daily pill help breast cancer that outsmarts two antibody drugs?
Disease control OngoingResearchers are reviewing medical records to see how well pyrotinib works and how safe it is in people with HER2-positive advanced breast cancer whose disease worsened after treatment with trastuzumab and pertuzumab. The study includes about 200 patients in China who received pyr…
Matched conditions: HER2-POSITIVE ADVANCED BREAST CANCER
Sponsor: Beijing 302 Hospital • Aim: Disease control
Last updated Sep 11, 2026 00:00 UTC
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Targeted combo aims to replace chemo in HER2+ breast cancer
Disease control OngoingThis Phase 3 trial tests whether a combination of targeted drugs (trastuzumab, alpelisib, and possibly fulvestrant) can work better than standard chemotherapy for people with a specific genetic mutation (PIK3CA) in HER2+ advanced breast cancer. The study enrolled 27 participants …
Matched conditions: HER2-POSITIVE ADVANCED BREAST CANCER
Phase 3 • Sponsor: Spanish Breast Cancer Research Group • Aim: Disease control
Last updated Jun 26, 2026 15:03 UTC
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New study: can a pill stop chemo nausea in advanced breast cancer?
Symptom relief By invitation onlyThis study looks at whether the anti-nausea drug NEPA (netupitant/palonosetron) can prevent vomiting and nausea in people with advanced HER2-positive or HER2-low breast cancer who are receiving the drug T-DXd. It will follow 100 participants across multiple hospitals to see how w…
Matched conditions: HER2-POSITIVE ADVANCED BREAST CANCER
Sponsor: Yeon Hee Park • Aim: Symptom relief
Last updated Jun 27, 2026 08:09 UTC