HEPATITIS B

This early-stage study tests whether HEPLISAV-B, a vaccine normally used to prevent hepatitis B, is safe in people who already have chronic hepatitis B. Ten adults on antiviral therapy will receive two vaccine shots and be monitored for side effects and immune responses over 14 m…

This early-stage study tests a single dose of a new antibody (HepB mAb19) in 37 adults with chronic hepatitis B who are already on standard antiviral pills. The main goals are to check safety and how the body processes the antibody, while also looking at its ability to lower viru…

This study compares two antiviral medications, tenofovir alafenamide (TAF) and entecavir (ETV), in 140 adults with chronic hepatitis B. The goal is to see which drug better suppresses the virus and is safer for the kidneys. Participants will take one of the two drugs and be monit…

This early-stage study tests whether stem cells from umbilical cords are safe and can help people with liver damage caused by hepatitis B. About 20 adults aged 18-60 with moderate to severe cirrhosis will receive the stem cell treatment. The main goal is to check safety and see i…

This study is testing whether a dried blood spot (a drop of blood on a card) can effectively screen for hepatitis B, hepatitis C, and AIDS in people who use drugs. The goal is to make screening easier and more accessible for this group. Researchers will enroll 500 current or form…

This study tests whether a blood test (GALAD) is better than ultrasound for finding liver cancer early in 5500 people with cirrhosis or chronic hepatitis B. Participants will be randomly assigned to one of two screening methods every six months. The goal is to see which approach …

This study follows 390 adults in Zambia with hepatitis B, some also with HIV, to see how their liver and viruses change over time. Participants join when diagnosed or starting standard antiviral treatments and are monitored for years. The goal is to understand the disease better,…

This study is creating a large collection of blood samples and health information from 3500 people with hepatitis B. Researchers will use these samples to measure and study viral RNAs, hoping to find a new way to tell if someone is functionally cured. No new treatments are tested…

This study follows up to 8,050 people with or at risk for liver disease (like hepatitis B, C, or D) to learn how these conditions develop and progress. Participants give blood and urine samples, get yearly liver ultrasounds, and may have optional biopsies. The goal is to gather i…

This study looks at the medical records of 15,000 people to understand how chronic liver diseases (like hepatitis, fatty liver, and cirrhosis) are connected to other health problems. Researchers will track who develops liver cancer or serious liver complications over time. The go…

This study looks at how the body processes a single dose of bepirovirsen, a drug for hepatitis B, in people with different levels of kidney function. About 32 adults with either severe or moderate kidney disease, or healthy kidneys, will take part. The goal is to see if kidney pr…