HEPATIC INSUFFICIENCY

This early-stage study aimed to understand how a drug called bomedemstat (MK-3543) behaves in people with mild or moderate liver impairment. Researchers gave a single dose to 9 participants—some with liver problems and some healthy—and tracked the drug levels in their blood over …

This study tested how liver problems affect how the body processes a single dose of an experimental medicine called iclepertin, which is being developed for brain diseases. It involved 29 adults, some with mild to moderate liver impairment and others with normal liver function, t…

This study aimed to understand how a breast cancer drug, imlunestrant, is processed by the body in people with different levels of liver function. It compared the drug's levels in the blood of women with impaired livers to those with healthy livers. The goal was to gather safety …

This study aims to understand how liver disease changes the way the body processes an experimental cancer drug called sevabertinib. Researchers compared about 20 people—half with moderate liver problems and half with healthy livers—after each took a single dose. By measuring drug…

This early study aimed to understand how a new drug, olomorasib, is processed by people with different levels of liver impairment compared to healthy people. It involved 46 participants who received a single dose, with a focus on measuring drug levels in the blood and checking fo…

This study tested how a medicine called BI 1015550 behaves in people with and without liver problems. Researchers compared 28 adults with mild or moderate liver impairment to matched healthy participants, giving everyone a single dose. They measured drug levels in the blood over …