HEMORRHAGE

This study tests a special gel called Onyx™ LES to stop active bleeding in arteries outside the brain and heart. About 119 adults with severe bleeding from trauma, ulcers, or other causes will receive the gel during a procedure. The goal is to see if it safely stops bleeding with…

This study tests whether giving a clotting protein called factor XIII early can reduce blood loss in women with heavy bleeding after childbirth. About 988 women having a vaginal delivery in Switzerland will take part. Those who continue bleeding after standard care will either re…

This study tests whether giving calcium before reaching the hospital and vasopressin early in the hospital can help people with severe bleeding after a traumatic injury. About 1,050 participants at risk of hemorrhagic shock will be enrolled. The goal is to see if these treatments…

This study tests whether a new patch called TachoSil works better than a widely used product (Surgicel) to stop mild to moderate bleeding during surgery. About 116 adults having open abdominal, pelvic, chest, or certain transplant surgeries will take part. The main goal is to see…

This study looks at people with atrial fibrillation who get a procedure to close a part of the heart (left atrial appendage) to lower stroke risk. Instead of taking standard blood thinners for life, participants take a lower dose of apixaban for just 3 months and then stop all bl…

This study tests whether improved oral hygiene combined with antibiotics can prevent pneumonia in people who have had a brain hemorrhage. About 440 adults with small to moderate brain bleeds will be randomly assigned to receive either standard care or enhanced mouth care plus ant…

This study tests a new method called U-CaVIT, which uses a balloon placed in the uterus to prevent severe bleeding after a C-section in women at high risk. About 70 participants will either get standard care or standard care plus the balloon. The goal is to see if the balloon hel…

This study tests a non-invasive light-based device to monitor blood flow and oxygen use in the brains of premature infants who have had a brain bleed or developed fluid buildup (hydrocephalus). Researchers will compare these babies to healthy newborns and those with other causes …

This study tests a special monitor (Mostcare®) that measures blood flow continuously in children after surgery. The goal is to see if it can predict whether a child needs more fluids, compared to the standard ultrasound method. About 100 children aged 0-10 years who are on breath…

This study looks at 30 infants, aged 3-8 months, having surgery to correct craniosynostosis (early skull bone fusion). Researchers want to see if a new monitoring method (PRAM) can better detect dangerous changes in blood pressure and blood loss compared to standard monitoring. T…

This study aims to create a complete artificial blood substitute that can be used when real blood is not available. Researchers will combine lab-made oxygen carriers, plasma, and platelets to mimic natural whole blood. The work is done in the lab with 250 healthy adults providing…