Heart transplant

This trial compares two anesthesia approaches for adults undergoing heart transplantation: a newer method that avoids routine breathing tubes and lets patients breathe on their own sooner, versus conventional anesthesia with a breathing tube. The goal is to see if the gentler met…

This phase 2 trial tests whether a drug called belatacept, combined with a gradual reduction of tacrolimus, can safely prevent organ rejection in heart transplant recipients while protecting kidney function. About 66 adults who receive a new heart will be randomly assigned to eit…

This study tests if giving blood thinners (aspirin or clopidogrel) soon after a heart transplant can prevent a common complication called cardiac allograft vasculopathy, which narrows the heart's arteries. About 135 adult heart transplant recipients will be randomly assigned to r…

This study tests a device that keeps donor hearts functioning outside the body without stopping blood flow. It aims to safely use hearts from extended-criteria donors (e.g., older or with other health issues) for transplant. Sixty adult heart transplant recipients will receive a …

This study tests whether empagliflozin (Jardiance), a drug used for diabetes, can protect the kidneys and heart in people who have had a heart transplant. About 200 veterans will take either the drug or a placebo daily for 12 months. The goal is to see if it improves kidney funct…

This study tests a special machine and solution that keeps donor hearts in better condition during transport, compared to the usual ice-cooler method. The goal is to see if it helps the heart work well right after transplant and improves survival at 30 days. About 655 people rece…

This study tests whether a 12-week resistance training program can improve physical function, quality of life, and heart-related biomarkers in people with heart failure who are on the waiting list for a heart transplant. Participants will be randomly assigned to either the exerci…

This study looks at whether cardiac MRI and blood tests can detect acute rejection in children and young adults who have had a heart transplant. Currently, doctors often use invasive heart biopsies to check for rejection, which can be uncomfortable and risky. The goal is to see i…

This study is recruiting 90 people aged 8-25 who are survivors of childhood leukemia, chronic lung disease of prematurity, or heart transplant, plus healthy controls. Researchers will use non-invasive exercise tests to measure heart and lung function during physical activity. The…

This registry will follow up to 100,000 heart transplant recipients to compare outcomes when donor hearts are preserved using the OCS Heart system versus traditional cold storage. The goal is to see if the OCS Heart system, which keeps donor hearts warm and beating during transpo…