HEART TRANSPLANT

This study tests a new machine that keeps donor hearts healthy outside the body before transplant. It focuses on hearts from donors who may not usually qualify, aiming to safely increase the number of available hearts. About 60 adults waiting for a heart transplant will take part…

This study tests whether starting blood thinners (antiplatelet drugs) soon after a heart transplant can prevent a common complication called cardiac allograft vasculopathy, which narrows the heart's arteries. About 135 adult heart transplant recipients will be randomly assigned t…

This study looks at two ways to deliver cardiac rehabilitation—a program of exercise, education, and counseling for people with heart conditions. One method is in-person at a clinic, the other is done remotely via telehealth. The goal is to see if both approaches are equally effe…

This study tests a new device and solution that keeps donor hearts healthy outside the body before transplant. It includes 655 heart transplant patients and compares the new method to standard cold storage. The goal is to see if the device helps the heart work better right after …

This study tests whether a drug called belatacept can safely replace the standard anti-rejection drug tacrolimus over time in heart transplant patients. The goal is to prevent organ rejection while reducing kidney damage often caused by tacrolimus. About 66 adults receiving their…

This study compares two different exercise training programs for people who have recently had a heart transplant. The goal is to see which program is safer and more effective at improving recovery and reducing serious health events like rejection or hospitalization. The study wil…

This study tests whether empagliflozin, a drug used for diabetes, can protect the kidneys and heart in people who have had a heart transplant. About 200 veterans will receive either the drug or a placebo daily for 12 months. The goal is to see if it improves kidney function and r…

This study looks at how the heart and lungs work during exercise in young people (ages 8-25) who have survived a heart transplant, leukemia, or were born with chronic lung disease. Researchers will use special tests to measure oxygen use and heart function while participants exer…

This study is a large registry that will follow up to 100,000 heart transplant recipients to compare outcomes between hearts preserved using the Organ Care System (OCS) machine and those preserved with standard cold storage. The goal is to see if OCS leads to better patient and g…