HAEMATOLOGICAL MALIGNANCY

This study tests a new drug called CCS1477 in people with advanced blood cancers like leukemia, lymphoma, and multiple myeloma that have not responded to standard treatments. The main goals are to check the drug's safety and find the right dose. About 250 participants will receiv…

This study tests a drug called alectinib, already approved for some lung cancers, in people with other rare cancers that have a specific gene change (ALK). About 30 adults, teens, and children will receive the drug to see if it shrinks tumors or stops cancer growth for at least 2…

This trial tests whether a combination of two drugs, vemurafenib and cobimetinib, can shrink or control rare cancers that have a specific BRAF V600 mutation. The drugs are already approved for melanoma, and researchers want to see if they help people with other cancer types, like…

This trial tests two drugs, trastuzumab and pertuzumab, already approved for breast cancer, in people with rare cancers that have a specific genetic change called HER2 amplification or mutation. About 30 adults and children with various rare cancers will receive the drug combinat…

This study tests a drug called entrectinib, already approved for some lung cancers, in people with rare cancers that have a specific genetic change (ROS1 fusion). About 30 adults and children with these rare tumors will receive the drug. Researchers will measure if tumors shrink …

This study tests capmatinib, a drug already approved for certain lung cancers, in adults with other rare cancers that have specific MET gene changes. About 30 participants will receive the drug to see if their tumors shrink or stop growing for at least 24 weeks. The goal is to fi…

This study tests whether using a patient's genetic information to dose the antifungal drug voriconazole can help more patients reach the right drug level in their blood compared to standard dosing. The trial will enroll about 104 children and adults with blood cancer or fungal in…

This study tests whether drugs already approved for some cancers can help people with rare cancers or common cancers that have rare genetic changes. It is open to adults, teenagers, and children whose cancer has a specific mutation and who have run out of standard options. The go…