GLIOBLASTOMA MULTIFORME, ADULT

This phase III trial is testing whether delivering the drug bevacizumab (Avastin) directly to the brain through a catheter, along with standard chemo and radiation, can help people with newly diagnosed glioblastoma live longer. The study will enroll 432 adults with this aggressiv…

This study tests a new approach for people with a recently removed glioblastoma (a fast-growing brain tumor). Doctors take some of the patient's own blood stem cells, add a protective gene (P140K MGMT) to them, and return them to the patient. This allows the use of higher doses o…

This study tests if using focused ultrasound (sound waves) can help the drug Avastin work better for people with recurrent glioblastoma, an aggressive brain cancer. About 32 adults will either get Avastin alone or Avastin plus the ultrasound treatment. The goal is to see if the c…

This study tests a new drug, TLX101-Tx, that delivers radiation directly to glioblastoma cells. It is combined with standard chemotherapy (lomustine) and compared to chemotherapy alone in 50 adults whose brain cancer has returned after initial treatment. The goal is to see if the…

This study tests a new surgical technique for people with glioblastoma, an aggressive brain cancer. Surgeons place a piece of the patient's own tissue (from the scalp or skull lining) into the area where the tumor was removed. This tissue flap may help bypass the blood-brain barr…

This study tests whether giving a higher radiation dose to the most aggressive parts of a glioblastoma tumor, as seen on a special FDOPA PET scan, can help people live longer. It includes 75 adults who are too frail for standard treatment or had only a partial surgery or biopsy. …

This study tests whether adding the drug ruxolitinib to standard treatment (radiation and temozolomide) helps people with newly diagnosed glioblastoma live longer. About 190 adults will be randomly assigned to receive either the standard treatment alone or standard treatment plus…