Foot ulcer

This phase 2 trial tests whether photobiomodulation, a type of light therapy, can improve healing of foot ulcers in people with diabetes. Researchers will compare standard wound care alone against standard care plus light therapy applied to the ulcer and to blood vessels. The stu…

This study tests whether adding a placental-based skin substitute to standard wound care helps close hard-to-heal diabetic foot ulcers faster than standard care alone. About 272 adults with diabetes and a foot ulcer present for 4 to 52 weeks will receive either the skin substitut…

This study tests whether a special graft made from donated placental tissue, called XWRAP, can help heal diabetic foot ulcers that won't close with standard care alone. About 60 adults with type 1 or type 2 diabetes will receive either the graft plus standard wound care or standa…

This study is testing a special soft cast for people with diabetic foot ulcers. The cast is a multi-layer wrap that cushions the foot and leg to help the wound heal. Researchers want to see if it works well, is comfortable, and safe. About 100 adults with diabetic foot ulcers wil…

This Phase 3 study tests whether a gel called ENERGI-F703 can help close diabetic foot ulcers better than a placebo gel. About 230 adults with diabetes and a foot ulcer that hasn't healed for at least 4 weeks will receive either the active gel or a placebo, along with standard wo…

This pilot study investigates how the design of removable cast walkers—used to offload diabetic foot ulcers—affects how often patients wear them and how well the ulcers heal. Researchers will compare a knee-high walker with an ankle-high version paired with a shoe lift, measuring…

This study is testing whether photos taken with a smartphone and thermal camera can accurately measure the size of diabetic foot ulcers. Researchers will compare the software's estimates to actual measurements. The goal is to see if this method could allow patients to monitor the…

This study tests a new imaging device that uses light and sound to check blood flow in foot wounds. The goal is to see if this tool can help doctors decide on better treatments. About 25 people with chronic foot ulcers will take part. This is a small early study to see if the ide…