FAMILIAL HYPERCHOLESTEROLEMIA

This Phase 3 study tested whether adding an investigational drug called MK-0616 (enlicitide) to standard statin therapy could better lower 'bad' LDL cholesterol in adults with a genetic form of high cholesterol. Over 300 participants were randomly assigned to receive either the d…

This large study tested whether an experimental drug called MK-0616 could safely lower 'bad' cholesterol (LDL-C) in adults with high cholesterol. Nearly 3,000 participants, who were already on standard cholesterol medications, received either the drug or a placebo for 24 weeks. T…

This study tested whether switching to a whole food plant-based diet could lower 'bad' LDL cholesterol in adults with a genetic condition causing very high cholesterol. For the study, 50 participants stopped their cholesterol medication and tried two different diets for four week…

This pilot study tested whether a specific heart-healthy diet, with or without added supplements (phytosterols and krill oil), could help lower cholesterol in adults with a genetic form of high cholesterol (familial hypercholesterolemia). All 58 participants were already on stabl…

This large, completed Phase 3 trial tested whether a new drug called obicetrapib could help people with high cholesterol and heart disease who weren't getting enough benefit from their current medications. Over 2,500 participants took either the new pill or a placebo (a dummy pil…

This was the first study in people to test the safety of an experimental drug called ARO-ANG3, which is designed to lower unhealthy cholesterol and triglyceride levels. It involved 93 healthy volunteers and patients with high cholesterol or triglycerides. The main goal was to see…

This study tested whether a new combination pill containing two drugs (obicetrapib and ezetimibe) could lower 'bad' cholesterol (LDL-C) more effectively than a placebo or either drug alone. It involved 407 adults with a genetic cholesterol disorder (HeFH) or established heart dis…

This was a first-in-human study to check the safety and basic effects of a single dose of an experimental drug called VSA003. It involved 36 healthy Chinese adult volunteers. The main goal was to see how the body processes the drug and to monitor for any side effects.