FAMILIAL HYPERCHOLESTEROLEMIA

This study looked at whether a whole food plant-based diet, low in red and processed meats, can lower LDL cholesterol in 50 adults with heterozygous familial hypercholesterolemia (HeFH), an inherited condition causing high cholesterol. Participants followed both a standard North …

This study tested an experimental drug called MK-0616 in nearly 3,000 adults with high cholesterol. The goal was to see if it could safely lower 'bad' LDL cholesterol more than a placebo over 24 weeks. Participants either had a history of heart disease or were at high risk, and m…

This phase 3 study tested a daily pill that combines two drugs, obicetrapib and ezetimibe, in 407 adults with inherited high cholesterol or heart disease who were already on maximum cholesterol-lowering therapy. The goal was to see if the combination could further lower LDL (bad)…

This study tested a new drug called obicetrapib in over 2,500 adults with high cholesterol or heart disease whose cholesterol was not well-controlled by their current medications. Participants took either the drug or a placebo pill daily for about 6 months. The main goal was to s…

This early-stage study tested a new drug called ARO-ANG3 in 93 healthy adults and patients with high cholesterol or high triglycerides. The main goal was to check safety and how the drug moves through the body. Researchers gave single or multiple doses to see if it could help con…

This study tested a new medication called MK-0616 in 303 adults with a genetic condition that causes very high cholesterol (heterozygous familial hypercholesterolemia). Participants took either the drug or a placebo, and researchers measured how much their bad cholesterol (LDL-C)…

This pilot study tested whether a Brazilian heart-healthy diet, with or without added plant sterols and krill oil, can improve cholesterol levels in people with familial hypercholesterolemia (a genetic condition causing very high cholesterol). 58 adults with this condition were r…

This study tested whether offering genetic testing for familial hypercholesterolemia (a genetic condition causing very high cholesterol) to people hospitalized for a heart attack could help doctors diagnose the condition more often. Researchers enrolled 140 patients under age 60 …

This early-phase study tested a single dose of VSA003 in 36 healthy Chinese adults with mildly high cholesterol or triglycerides. The main goal was to check safety and how the drug moves through the body, not to treat the condition. Participants were monitored for side effects an…

This study involved 162 teens and their parents to understand how they feel after learning about genetic risks for conditions like breast cancer, Lynch syndrome, and high cholesterol. Researchers used surveys and interviews to measure anxiety, depression, family functioning, and …