ESR1 GENE MUTATION
Clinical trials for ESR1 GENE MUTATION explained in plain language.
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Smart imaging may help overcome drug resistance in breast cancer
Disease control Recruiting nowThis study tests whether a special PET scan can help find the best dose of tamoxifen for people with metastatic breast cancer that has an ESR1 mutation. These mutations can make standard tamoxifen doses less effective. The study will enroll 12 participants and use FES-PET/CT imag…
Matched conditions: ESR1 GENE MUTATION
Phase: EARLY_PHASE1 • Sponsor: University of Wisconsin, Madison • Aim: Disease control
Last updated May 26, 2026 03:21 UTC
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Promising combo aims to slow advanced breast cancer
Disease control Recruiting nowThis study tests whether adding everolimus to elacestrant can help people with a certain type of advanced breast cancer (ER+/HER2-, with an ESR1 mutation) live longer without their cancer growing. About 240 adults whose cancer has worsened after standard treatments will receive e…
Matched conditions: ESR1 GENE MUTATION
Phase: PHASE3 • Sponsor: MedSIR • Aim: Disease control
Last updated May 26, 2026 03:11 UTC
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New combo aims to outsmart resistant breast cancer
Disease control Recruiting nowThis study tests whether adding elacestrant to standard chemotherapy (capecitabine) can help people with advanced estrogen receptor-positive (ER+) breast cancer that no longer responds to CDK 4/6 inhibitors. About 297 participants will be randomly assigned to get either the combi…
Matched conditions: ESR1 GENE MUTATION
Phase: PHASE2 • Sponsor: Kristina A. Fanucci • Aim: Disease control
Last updated May 22, 2026 13:52 UTC