Down syndrome (trisomy 21)
Clinical trials for Down syndrome (trisomy 21) explained in plain language.
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Can an immune-targeting antibody reverse sudden losses in down syndrome?
Disease control Not yet recruitingDown syndrome regression disorder (DSRD) causes a sudden loss of thinking, language, or daily skills in some people with Down syndrome. Researchers are testing ublituximab, an antibody that targets immune cells, in 20 adults aged 18 to 40 who have DSRD and did not respond well en…
Matched conditions: DOWN SYNDROME (TRISOMY 21)
Phase 2 • Sponsor: Jonathan Santoro • Aim: Disease control
Last updated Sep 12, 2026 00:00 UTC
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Could a drug clear Alzheimer's plaques in people with down syndrome?
Disease control Not yet recruitingThis study tests whether donanemab, given as an IV infusion every 4 weeks, can safely lower amyloid plaques in the brains of 60 adults aged 35–50 with Down syndrome. Participants receive either donanemab or a placebo for 12 months, followed by a 12-month extension where everyone …
Matched conditions: DOWN SYNDROME (TRISOMY 21)
Phase 4 • Sponsor: Michael Rafii, MD, PhD • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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Could a pacifier help babies with down syndrome breathe better at night?
Prevention Not yet recruitingThis study tests whether a special pacifier, called CURAPROX, can reduce the severity of obstructive sleep apnea (OSA) in infants with Down syndrome. Fifty infants will be enrolled at one month old, with half using the pacifier and half not. At six months, sleep tests will measur…
Matched conditions: DOWN SYNDROME (TRISOMY 21)
Sponsor: Hospices Civils de Lyon • Aim: Prevention
Last updated Jun 27, 2026 14:00 UTC