CUSHING SYNDROME

This study tests a drug called osilodrostat in children aged 2 to 17 with Cushing's syndrome, a condition where the body makes too much cortisol. The goal is to see how the drug works in the body and if it can safely lower cortisol levels. About 12 children will take the drug for…

This study will measure cortisol in saliva from 220 healthy adults to establish normal reference ranges. Researchers will also determine the best cut-off values to diagnose Cushing's syndrome and adrenal insufficiency. The goal is to improve accuracy and ease of testing for these…

This study is checking how well a test called the desmopressin stimulation test can identify different types of Cushing's syndrome, a condition caused by too much cortisol. Researchers will give the test to 140 people aged 18 to 70 who have or might have Cushing's, as well as hea…

This study is creating a large database to collect information about people with rare diseases like amyloidosis, sarcoidosis, and many others. Researchers will track patients' health, treatments, and outcomes over time. The goal is to better understand these conditions and improv…

This study follows 700 adults having curative surgery for Cushing syndrome to understand how long it takes for the body's natural hormone system to recover. Researchers will track symptoms of hormone withdrawal and quality of life. The goal is to find factors that predict faster …

This study is creating a registry of 300 people with Cushing's syndrome to follow their health over time during routine care. Researchers will collect data before and after treatments like surgery, medication, or radiation to understand long-term outcomes. The goal is to learn mo…

This study aims to better understand how adrenal tumors develop and to evaluate new treatment options for adrenal cancer. Researchers will enroll 500 people who have an adrenal tumor seen on imaging. The goal is to improve care for patients with these rare tumors.