Clinical high risk for psychosis (CHR)

This study is testing an experimental drug called MT1988 in 150 people aged 17 to 30 who are at high risk of developing psychosis. Participants take either a low dose, high dose, or placebo pill twice daily for 8 weeks. The main goal is to see if certain tests (like memory and sy…

Researchers at Mount Sinai are testing whether a systematic screening program combined with a structured way of communicating with patients and families can shorten the time between the start of psychotic symptoms and the beginning of treatment. The trial enrolls people ages 12 t…

Researchers are testing an 8-week online program that teaches mindfulness, emotional regulation, distress tolerance, and interpersonal skills to people aged 14 to 35 who show early signs of psychosis risk. Participants are randomly assigned to the digital dialectical behaviour th…

This trial tests whether an accelerated form of brain stimulation, called intermittent theta burst stimulation (iTBS), is safe and feasible for young people at clinical high risk for psychosis. Participants receive either active or sham stimulation over five days, targeting a bra…

This study is testing whether cognitive behavioral therapy (CBT) delivered via telehealth can help young people aged 14 to 25 who are at clinical high risk for psychosis. Participants will receive group, family, or individual CBT sessions online. The goal is to see if this approa…

This study tests whether computer-based cognitive training, combined with group therapy, can improve thinking skills and daily functioning in Tunisian youth at clinical high risk for psychosis. Fifty-four participants will either receive the cognitive training program or an enhan…

This study aims to validate a French version of a questionnaire that helps detect very early signs of psychosis risk in teenagers aged 12 to 17. Researchers will check if different clinicians give consistent ratings when using the tool. The goal is to improve early detection and …

This study interviews 20 people aged 15–30 who are at ultra-high risk for psychosis or have had a first episode. They all took part in a group mindfulness program. Researchers want to understand their personal experiences and any possible downsides, using a detailed interview met…