Chronic rhinosinusitis with nasal polyps (CRSWNP)

This trial asks whether taking low-dose oral azithromycin after sinus surgery can lower the chance of nasal polyps returning in people with chronic rhinosinusitis. Adults with severe disease who have had functional endoscopic sinus surgery will receive either azithromycin three t…

This trial is testing an experimental drug called AK139, given as an injection, in people with chronic sinusitis and nasal polyps—growths in the nose that block airflow. The study compares AK139 against a placebo, with all participants also using a standard steroid nasal spray. T…

This study observes 210 patients in South Korea who are prescribed Tezepelumab for severe asthma or chronic sinusitis with nasal polyps. Researchers will track side effects and how well the drug controls symptoms in everyday use. The goal is to confirm the drug's safety and effec…

This study looks at whether taking the drug stapokibart for 4 weeks before sinus surgery helps adults with chronic nasal polyps more than surgery alone. About 48 participants will receive either the drug or a placebo before their operation and be followed for nearly a year. The g…

This study compares two treatments for chronic sinusitis with nasal polyps: a less invasive surgery (simple polyp removal) combined with an anti-IL-5 drug (mepolizumab) versus extensive sinus surgery also with the drug. About 360 participants will be randomly assigned to one of t…

Researchers are testing whether functional MRI can detect changes in the brain's smell-processing regions after people with severe chronic rhinosinusitis with nasal polyps receive monoclonal antibody treatment. The study enrolls 40 adults with smell loss who are eligible for biol…

This study tests an experimental drug called LP-003 for people with long-term sinus inflammation and nasal polyps (growths in the nose). The goal is to see if it can shrink polyps and reduce stuffiness. About 150 adults will receive either the drug or a placebo, and their progres…

This study follows about 1,000 adolescents and adults in China with severe chronic rhinosinusitis with nasal polyps, a condition causing nasal blockage, loss of smell, and poor quality of life. Over 36 months, researchers will track the treatments patients actually receive, such …

This study looks at whether measuring the thickness (viscosity) of nasal mucus can help doctors better understand the type of inflammation in people with chronic sinusitis and nasal polyps. Researchers will compare mucus from 60 patients having sinus surgery—some with polyps and …