Chronic kidney disease (stages 4 and 5)

This pilot study will test whether a healthy plant-based diet without strict potassium limits is safe for people with advanced chronic kidney disease (stages 4-5). Thirty participants will be assigned to either a liberal plant-based diet or a traditional potassium-restricted diet…

This study tests whether a simple home exercise program can prevent memory and thinking problems from getting worse in people with advanced chronic kidney disease (stages 4-5). 124 participants will either do low-intensity walking and strength exercises or receive standard care. …

People with advanced kidney disease often face fatigue, itching, pain, and sleep problems that disrupt daily life and strain caregivers. Researchers are testing a nurse-led program called COMFORT that helps patients and their informal caregivers recognize and manage these symptom…

Researchers are testing whether a breathing muscle training program done during hemodialysis can improve breathing strength and physical function in adults with advanced kidney disease. Participants train with a handheld electronic device three times a week for 12 weeks while rec…

This trial tests whether adding palliative care to standard treatment helps people with advanced chronic kidney disease (stages 4 and 5, including those on dialysis) feel better. Participants are randomly assigned to receive either usual kidney care or usual care plus integrated …

This study tests whether adding a special breathing feedback device to standard breathing exercises can reduce symptoms and improve quality of life in adults with chronic kidney disease. Twenty-four participants will practice the exercises three times daily for six weeks. The goa…

This trial explores whether a training program for general practitioners can improve how primary care clinics deliver palliative care to adults with advanced cancer, COPD, heart failure, or kidney disease. One family health unit will use the new approach—a 30-hour e-learning cour…

This observational study will measure thyroid hormone levels in stored blood and urine samples from 51 people with severe chronic kidney disease (stages 4 and 5). Researchers aim to understand how these hormones differ in patients with and without polycystic kidney disease. The s…

APT-KIDNEY is a large, flexible clinical trial platform designed to test multiple treatments for advanced kidney disease more efficiently. It will enroll up to 5,000 adults with severe kidney problems or those on dialysis. By using electronic health records and adaptive methods, …

This study tests how the diabetes drug canagliflozin (Invokana) spreads through the body in 10 dialysis patients with severe kidney disease. Using PET scans, researchers want to see if the drug reaches tissues like the heart and blood vessels, not just the kidneys. The goal is to…

This study looks at whether a new way of measuring kidney function (using an injection of iohexol and finger-prick blood tests) can better predict when people with advanced kidney disease will start feeling sick from kidney failure. It also checks if this method can accurately me…