BREAST RECONSTRUCTION

This study tests a device called ARTIA, a special tissue matrix used during breast reconstruction after mastectomy. About 264 adults who need immediate implant-based reconstruction will receive ARTIA. Researchers will track major complications and patient satisfaction to see if A…

This study is testing a device called OviTex PRS, made from sheep stomach tissue and polymer thread, for women having breast reconstruction after mastectomy. The goal is to see if it is safe and effective at reducing complications like reconstructive failure. About 235 women will…

This study tests whether hyperbaric oxygen therapy (HBOT) can help transplanted fat survive better in breast reconstruction for women who had radiation therapy. Sixteen women will each receive two fat grafting sessions—one with HBOT and one without—and have MRIs to measure how mu…

This study is testing a surgical procedure that combines fat grafting with a muscle flap from the back to rebuild the breast after mastectomy. The goal is to see if this approach leads to fewer wound problems. Twenty women who had a skin-sparing mastectomy will take part.

This study tests a special material (acellular dermal matrix) used in a two-stage breast reconstruction procedure for women who have had a mastectomy. The goal is to see if it reduces complications like infections or the need for extra surgeries, and improves quality of life. Abo…

This study looks at a new material called SC DERM® Recon, used in breast reconstruction surgery after mastectomy for breast cancer. Researchers want to see if it causes fewer short-term problems than similar materials. About 120 women will take part, and the study will track comp…

This study tests a special absorbable mesh that releases antibiotics to help prevent infections in women undergoing two-stage breast reconstruction after mastectomy. About 702 women will be randomly assigned to receive either standard care or the new mesh. The goal is to see if t…

This study tests whether applying minoxidil (a hair growth drug) to the breasts for two weeks before surgery can improve blood flow and tissue survival in women undergoing preventive mastectomy with reconstruction. Twenty-five women at high genetic risk for breast cancer will hav…

This study tests whether a short educational video about safe opioid use can help breast reconstruction patients use fewer painkillers after surgery. About 68 women will be randomly assigned to watch the video or receive standard care. Researchers will track how many opioids they…

This study tests if using a pulsed lavage (a high-pressure washing device) to clean the surgical pocket during implant-based breast reconstruction can lower the risk of complications like infection, bleeding, fluid buildup, or implant failure. Researchers will compare outcomes in…

This study compares two types of nipple-sparing mastectomy (keeping the nipple) for women with breast cancer or high genetic risk: one done with a robot through a single small cut, and the other with standard open surgery. All participants will also have immediate breast reconstr…

This study compares two types of nerve blocks—paravertebral and pectoral—to see which one better reduces pain and improves physical well-being in people having immediate implant-based breast reconstruction. About 212 adults scheduled for this surgery will be enrolled. The goal is…