BREAST CANCER STAGE II

This study tests a new approach for people with stage 2 or 3 breast cancer. Before standard chemotherapy, participants receive targeted radiation and an immunotherapy drug (pembrolizumab) injected into the tumor. The goal is to see if this combination can improve the chance of el…

This study tests whether a device called TheraBionic P1, which delivers targeted radio waves, can help shrink early-stage breast cancer before surgery. About 24 women with hormone receptor-positive, HER2-negative breast cancer will use the device daily for a short time before the…

This study tests a new drug called FWD1802 combined with other treatments for people with ER-positive/HER2-negative breast cancer that has spread or cannot be removed by surgery. About 196 participants will join to find safe doses and see if the combinations shrink tumors. The go…

This study tests whether drinking tart cherry juice can prevent nerve damage (neuropathy) caused by the chemotherapy drug paclitaxel in people with breast or ovarian cancer. About 86 participants will be randomly assigned to take either a high or low dose of the juice during thei…

This study tests whether eating all meals within an 8-hour window each day can improve how well cancer treatments work and reduce side effects. It will enroll 100 Alaska Native or American Indian adults with breast or rectal cancer. Participants will follow this time-restricted e…

This study tests whether combining the drug memantine with a structured exercise program can improve memory and thinking in breast cancer patients undergoing chemotherapy. About 90 women with early-stage breast cancer will be split into three groups: memantine plus exercise, mema…

This study tests an 8-week virtual rehab program (CaRE@Home) for cancer survivors who have finished treatment. It aims to reduce disability and improve physical function, anxiety, and quality of life. About 388 adults with breast, colorectal, head and neck cancer, or lymphoma wil…

This study looks at how the immune system responds in people with early-stage triple negative breast cancer who are receiving standard chemotherapy combined with immunotherapy (pembrolizumab). Researchers will measure certain immune markers in the blood and tumor tissue to see if…

This study looks at how to help young women (ages 18-44) newly diagnosed with breast cancer make better decisions about surgery. Researchers are testing a web-based tool called CONSYDER that gives helpful information and improves talks with surgeons. About 800 participants will f…

This study compares three types of remote medical interpreting to see which leads to the fewest errors during breast cancer appointments. It involves 700 Spanish- and Mandarin-speaking patients with limited English proficiency and their English-speaking doctors. The goal is to fi…

This study is for people with early-stage breast cancer (Stage I-III) who will receive hormone therapy before surgery. Researchers want to see how the cancer responds to this treatment and if they can predict the outcome using blood and tissue samples. Participants will be follow…

This study is developing and testing a decision aid tool for women diagnosed with early-stage breast cancer. The tool is designed to help them make informed choices about their treatment. Researchers will compare how well the tool works in a group of 180 women who use it versus t…