BRCA2 mutation
Clinical trials for BRCA2 mutation explained in plain language.
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Triple threat: new drug cocktail targets BRCA breast cancer
Disease control CompletedThis early-phase trial tested a combination of three drugs—olaparib, palbociclib, and fulvestrant—in 9 people with BRCA-mutated, hormone-positive, HER2-negative metastatic breast cancer. The main goal was to see if the combination is safe. Researchers also looked at how long the …
Matched conditions: BRCA2 MUTATION
Phase 1 • Sponsor: Abramson Cancer Center at Penn Medicine • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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A gene variant found mostly on one island could reshape breast cancer screening
Knowledge-focused CompletedResearchers want to know how common a BRCA2 gene mutation is among people diagnosed with breast cancer on Reunion Island. Earlier work found that more than half of patients there with a BRCA mutation carry a variant specific to the island's population. This study collects blood s…
Matched conditions: BRCA2 MUTATION
Sponsor: Centre Hospitalier Universitaire de la Réunion • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Toolkit aims to break the silence around inherited cancer genes
Knowledge-focused CompletedThis study tested whether a 'Disclosure Toolkit'—including a family letter, a chatbot, and a website—helps people with BRCA1 or BRCA2 mutations share their genetic test results with at-risk relatives. Researchers enrolled 52 participants to see if the toolkit improves communicati…
Matched conditions: BRCA2 MUTATION
Sponsor: University of Pennsylvania • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC