BRAF V600E
Clinical trials for BRAF V600E explained in plain language.
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New pill targets Hard-to-Treat cancers: early trial recruits 554 patients
Disease control Recruiting nowThis study tests an experimental oral drug called S241656 (BDTX-4933) in people with advanced solid tumors that have certain genetic changes (KRAS, BRAF, or other RAS/MAPK mutations). The trial has two parts: first, finding a safe dose, then testing how well it works alone or wit…
Matched conditions: BRAF V600E
Phase: PHASE1, PHASE2 • Sponsor: Institut de Recherches Internationales Servier • Aim: Disease control
Last updated Jun 23, 2026 20:46 UTC
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New cocktail aims to outsmart deadly colorectal cancer
Disease control Recruiting nowThis study tests a combination of four drugs (sintilimab, ipilimumab, cetuximab, and dabrafenib) in people with a specific type of advanced colorectal cancer that has a BRAF V600E mutation and is microsatellite stable. These cancers are hard to treat and don't respond well to sta…
Matched conditions: BRAF V600E
Phase: PHASE2 • Sponsor: Tianjin Medical University Cancer Institute and Hospital • Aim: Disease control
Last updated Jun 18, 2026 11:48 UTC
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Scientists peek inside lung tumors to outsmart drug resistance
Knowledge-focused Recruiting nowThis study looks at why some lung cancer cells survive targeted treatment. Researchers will take small tissue samples (biopsies) from 100 patients before and two weeks after starting therapy. By comparing the samples, they hope to find early signs of resistance and identify ways …
Matched conditions: BRAF V600E
Sponsor: University of Colorado, Denver • Aim: Knowledge-focused
Last updated Jun 17, 2026 12:03 UTC