Astrocytoma, IDH-mutant, grade 4
Clinical trials for Astrocytoma, IDH-mutant, grade 4 explained in plain language.
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Can a trio of repurposed drugs shrink recurrent brain tumors?
Disease control Recruiting nowResearchers are testing whether combining valproic acid, irinotecan, and simvastatin can shrink or stabilize recurrent glioblastoma and IDH-mutated glioma tumors. The trial enrolls 52 adults whose tumors have grown after prior treatment with radiation and chemotherapy. Participan…
Matched conditions: ASTROCYTOMA, IDH-MUTANT, GRADE 4
Phase 2 • Sponsor: Inova Health Care Services • Aim: Disease control
Last updated Sep 21, 2026 15:00 UTC
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New hope for brain tumor patients: targeted drug shows promise in phase 3 trial
Disease control Recruiting nowThis study tests a drug called safusidenib in people with a type of brain tumor (glioma) that has a specific gene mutation (IDH1). The trial has three parts: one for recurrent tumors, one for high-risk tumors after standard treatment, and one for a specific tumor type after surge…
Matched conditions: ASTROCYTOMA, IDH-MUTANT, GRADE 4
Phase 3 • Sponsor: Nuvation Bio Inc. • Aim: Disease control
Last updated Aug 30, 2026 00:00 UTC
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Promising drug combo targets Hard-to-Treat brain cancers
Disease control Recruiting nowThis study tests two drugs—retifanlimab (an immunotherapy) and DFMO (a growth blocker)—alone or together in 33 adults with progressive high-grade glioma, an aggressive brain cancer. The goal is to find the safest, most effective dose and see if the combination boosts the immune s…
Matched conditions: ASTROCYTOMA, IDH-MUTANT, GRADE 4
Phase 1/2 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jun 27, 2026 14:03 UTC
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New drug cocktail takes on deadly brain cancer
Disease control Recruiting nowThis trial is testing two experimental drugs, avutometinib and defactinib, alone or with a standard chemotherapy (temozolomide), in people with high-grade malignant brain tumours like glioblastoma. The study aims to find a safe dose and see if the drugs can shrink tumours or stop…
Matched conditions: ASTROCYTOMA, IDH-MUTANT, GRADE 4
Phase 1/2 • Sponsor: Institute of Cancer Research, United Kingdom • Aim: Disease control
Last updated Jun 27, 2026 08:12 UTC