Astrocytoma, IDH-mutant, grade 4
Clinical trials for Astrocytoma, IDH-mutant, grade 4 explained in plain language.
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Immunotherapy shows promise for tough brain cancers
Disease control OngoingThis study tests whether two immunotherapy drugs, ipilimumab and nivolumab, can shrink or slow the growth of recurrent high-grade gliomas (brain tumors) that have a high number of genetic mutations. About 37 adults with recurrent WHO grade 4 glioma will receive these drugs. The g…
Matched conditions: ASTROCYTOMA, IDH-MUTANT, GRADE 4
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Sep 02, 2026 00:00 UTC
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Can a targeted antibody take on glioblastoma?
Disease control OngoingThis phase 1 trial is testing whether amivantamab, an antibody drug given by IV, is safe and tolerable for people with high-grade malignant brain tumors like glioblastoma. The study enrolls about 12 patients with recurrent glioblastoma or certain molecular subtypes. Participants …
Matched conditions: ASTROCYTOMA, IDH-MUTANT, GRADE 4
Phase 1 • Sponsor: Institute of Cancer Research, United Kingdom • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC