ARDS (acute respiratory distress syndrome)
Clinical trials for ARDS (acute respiratory distress syndrome) explained in plain language.
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Can a smarter ventilator setting spare damaged lungs on ECMO?
Disease control Not yet recruitingThis pilot trial tests a ventilator strategy that targets a specific measure of lung stress, called mechanical power, in adults with severe ARDS who are on VV ECMO. The goal is to see if this approach is feasible and safe compared to standard ultra-low tidal volume ventilation. R…
Matched conditions: ARDS (ACUTE RESPIRATORY DISTRESS SYNDROME)
Sponsor: University of Virginia • Aim: Disease control
Last updated Sep 03, 2026 00:00 UTC
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Can matching drugs to biology beat ARDS?
Disease control Not yet recruitingThis trial tests whether two existing drugs, simvastatin and baricitinib, can help people with acute respiratory distress syndrome (ARDS), a severe lung condition that causes breathing failure. Participants are grouped by biological markers into subtypes, then randomly assigned t…
Matched conditions: ARDS (ACUTE RESPIRATORY DISTRESS SYNDROME)
Phase 2 • Sponsor: University of Colorado, Denver • Aim: Disease control
Last updated Sep 02, 2026 00:00 UTC
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Can varying breath size protect lungs on a ventilator?
Disease control Not yet recruitingThis trial tests whether a ventilator method called variable ventilation, which changes the size of each breath slightly, is safe and feasible for adults with acute respiratory distress syndrome (ARDS) who need breathing support. Participants receive 24 hours of variable ventilat…
Matched conditions: ARDS (ACUTE RESPIRATORY DISTRESS SYNDROME)
Sponsor: Brigham and Women's Hospital • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
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Immune cell infusion aims to free ARDS patients from ventilators
Disease control Not yet recruitingThis study tests an experimental therapy called GKL-006RTU, made from a type of immune cell (iNKT cells), for people with moderate to severe acute respiratory distress syndrome (ARDS), a life-threatening lung condition. The trial has two parts: first, a small group receives the c…
Matched conditions: ARDS (ACUTE RESPIRATORY DISTRESS SYNDROME)
Phase 1/2 • Sponsor: Beijing Gene Key Life Technology Co., Ltd • Aim: Disease control
Last updated Jul 18, 2026 00:00 UTC
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New ventilation strategy aims to reduce lung damage in severe pneumonia
Disease control Not yet recruitingThis study tests a new way of using a breathing machine (ventilator) called time-controlled adaptive ventilation (TCAV) in people with severe lung injury from pneumonia. The goal is to see if TCAV reduces fluid buildup in the lungs compared to standard ventilation. The trial invo…
Matched conditions: ARDS (ACUTE RESPIRATORY DISTRESS SYNDROME)
Sponsor: Central Hospital, Nancy, France • Aim: Disease control
Last updated Jul 03, 2026 00:00 UTC
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Could a common nausea drug shield ARDS lungs from further harm?
Disease control Not yet recruitingThis study tests whether ondansetron, a drug typically used for nausea, can reduce the strong urge to breathe in patients with acute respiratory distress syndrome (ARDS) who are on a ventilator. By lowering this drive, the drug may prevent patients from overworking their lungs an…
Matched conditions: ARDS (ACUTE RESPIRATORY DISTRESS SYNDROME)
Phase 2/3 • Sponsor: Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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New study tests best way to give muscle relaxants for severe lung failure
Disease control Not yet recruitingThis study looks at how to best give muscle relaxants to patients with severe lung failure (ARDS) who are on a breathing machine. It compares giving the drug as a steady drip versus as separate shots. The goal is to see which method is safer and works better, and to plan a larger…
Matched conditions: ARDS (ACUTE RESPIRATORY DISTRESS SYNDROME)
Phase 2 • Sponsor: University of Calgary • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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Scientists seek to unravel hidden subtypes of Sepsis-Linked lung failure
Knowledge-focused Not yet recruitingThis study will closely monitor 180 adults with sepsis-related acute respiratory distress syndrome (ARDS) who are on breathing machines. Researchers will take fluid samples from the lungs and blood at several time points to measure inflammation and injury markers. The goal is to …
Matched conditions: ARDS (ACUTE RESPIRATORY DISTRESS SYNDROME)
Sponsor: Hospital Universitari Vall d'Hebron Research Institute • Aim: Knowledge-focused
Last updated Aug 30, 2026 00:00 UTC
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Scientists build a biobank to decode ARDS and personalize treatment
Knowledge-focused Not yet recruitingThis study collects blood samples and health data from 1,200 adults with ARDS in intensive care. Researchers aim to identify biological markers that can group patients into subtypes and predict how they will respond to different treatments. The goal is to improve care for this li…
Matched conditions: ARDS (ACUTE RESPIRATORY DISTRESS SYNDROME)
Sponsor: Prenosis, Inc. • Aim: Knowledge-focused
Last updated Jul 02, 2026 00:00 UTC
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New study uses imaging to see how nitric oxide helps ARDS lungs
Knowledge-focused Not yet recruitingThis study looks at how a gas called nitric oxide, given through a mask or nasal tubes, changes the way air and blood flow match in the lungs of people with ARDS (a serious lung injury). Researchers will use a special imaging technique (EIT) to see these changes right away. The g…
Matched conditions: ARDS (ACUTE RESPIRATORY DISTRESS SYNDROME)
Sponsor: Ming Zhong • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:01 UTC
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Caribbean ECMO registry launches to track Life-Saving machine outcomes
Knowledge-focused Not yet recruitingThis study will collect information from 1,200 patients in the French West Indies and Guiana who received ECMO, a machine that helps the heart and lungs. Researchers aim to track survival rates and complications to better understand how ECMO works in this region. The study does n…
Matched conditions: ARDS (ACUTE RESPIRATORY DISTRESS SYNDROME)
Sponsor: University of Genova • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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New 3D scanner could reveal hidden lung danger in ventilator patients
Knowledge-focused Not yet recruitingThis study will use a new 3D imaging device (3D-EIT) to see if it can detect a pattern called 'cyclic on-off switching' of blood flow in the lungs of 40 adults with moderate to severe ARDS who are on mechanical ventilation. The goal is to validate whether this non-invasive, bedsi…
Matched conditions: ARDS (ACUTE RESPIRATORY DISTRESS SYNDROME)
Sponsor: Southeast University, China • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:09 UTC