Anterior cruciate ligament rupture
Clinical trials for Anterior cruciate ligament rupture explained in plain language.
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Which ACL graft gets young athletes back in the game faster?
Disease control OngoingThis trial compares two surgical techniques for ACL reconstruction in adolescents aged 12 to 19: using a quadriceps tendon graft with a bone block versus an all-soft-tissue graft. The goal is to see which approach leads to a quicker return to sports and a lower chance of re-ruptu…
Matched conditions: ANTERIOR CRUCIATE LIGAMENT RUPTURE
Sponsor: University of Colorado, Denver • Aim: Disease control
Last updated Jul 15, 2026 00:00 UTC
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Stem cells may boost ACL graft healing in new trial
Disease control By invitation onlyThis study tests whether adding a patient's own bone marrow stem cells during ACL reconstruction helps the graft heal better. One hundred adults with recent ACL tears will receive either stem cells or a sham procedure. The main goal is to see if the graft looks healthier on MRI a…
Matched conditions: ANTERIOR CRUCIATE LIGAMENT RUPTURE
Sponsor: Rush University Medical Center • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New ACL repair: does age matter?
Disease control OngoingThis study is testing a new way to repair torn ACLs called the BEAR procedure, where a special implant and the patient's own blood are used to help the ligament heal naturally. Researchers want to see if younger or older patients have better results two years after surgery. About…
Matched conditions: ANTERIOR CRUCIATE LIGAMENT RUPTURE
Sponsor: Miach Orthopaedics • Aim: Disease control
Last updated Jun 27, 2026 13:04 UTC
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New ligament could replace torn ACL without using your own tissue
Disease control By invitation onlyThis study tests a new regenerative ligament (CT-ACL001) for repairing a torn ACL, compared to the standard surgery. About 64 people aged 18-45 with a recent ACL injury will take part. The goal is to see if the new ligament works as well as the standard treatment and causes fewer…
Matched conditions: ANTERIOR CRUCIATE LIGAMENT RUPTURE
Sponsor: CoreTissue BioEngineering Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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Silence in the OR: headphones may speed up knee surgery
Symptom relief OngoingThis pilot study tests whether active noise-cancelling headphones and a closed-loop communication system can reduce operating time and improve teamwork during anterior cruciate ligament (ACL) reconstruction. Fifty-four patients having ACL surgery will be randomly assigned to eith…
Matched conditions: ANTERIOR CRUCIATE LIGAMENT RUPTURE
Sponsor: Fatih Sultan Mehmet Training and Research Hospital • Aim: Symptom relief
Last updated Sep 12, 2026 00:00 UTC
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Nerve block or pills? study tests which works best for ACL pain
Symptom relief By invitation onlyThis study looks at two common ways to manage pain after ACL knee surgery: a nerve block (injection near the knee) versus oral pain medication. About 60 adults aged 18 to 45 having ACL reconstruction will take part. The goal is to see if both methods provide similar pain relief a…
Matched conditions: ANTERIOR CRUCIATE LIGAMENT RUPTURE
Sponsor: University of California, Davis • Aim: Symptom relief
Last updated Aug 20, 2026 00:00 UTC