Aneurysmal subarachnoid hemorrhage

This phase 2 trial tests whether levosimendan, a heart medication that widens blood vessels, can reduce dangerous artery spasms and delayed brain injury after a type of bleeding stroke called aneurysmal subarachnoid hemorrhage. Thirty adults in intensive care will receive either …

This study tested whether a medicine called milrinone, given through a vein, can help people recover better from a serious type of stroke called subarachnoid hemorrhage. After this stroke, many patients develop dangerous spasms in brain arteries that can cause further brain damag…

This study tested whether giving a sedative called dexmedetomidine during a procedure to fix a brain aneurysm can prevent dangerous blood vessel spasms. 90 adults who had a brain bleed from a ruptured aneurysm took part. The goal was to see if the drug reduces complications and i…

This study tested whether tiopronin, a drug used for liver disease, can lower a harmful chemical in the brain and improve recovery after a bleeding stroke from a burst aneurysm. Sixty patients received either tiopronin or a placebo for up to 14 days. The goal was to see if the dr…

This study tested whether draining some fluid from the spine (a lumbar puncture) can help relieve severe headaches that often follow a brain aneurysm rupture. The trial involved 74 patients with mild to moderate brain bleeds. Half received a real lumbar puncture, and half receive…

Researchers are observing how two osmotic therapies, 20% mannitol and 10% hypertonic saline, affect outcomes in adults with severe subarachnoid hemorrhage, a type of bleeding around the brain. The study follows patients at multiple hospitals who receive standard care chosen by th…

Researchers are studying blood samples from people who have had a stroke to understand how blood clotting and inflammation affect recovery. They will take samples at several time points during the first week and measure markers of coagulation and inflammation. The goal is to see …

This study aimed to find genetic markers that could predict which patients will develop vasospasm—a dangerous narrowing of brain arteries—after a bleeding brain aneurysm. Researchers collected blood samples daily from 89 patients for 12 days to analyze their DNA and RNA. The goal…