ALZHEIMER DEMENTIA

This early-stage study tests a drug called CpG 1018 that aims to stimulate the immune system in people with mild cognitive impairment or mild Alzheimer's dementia. The main goal is to check the drug's safety and tolerability at three different dose levels. The study involves 39 p…

This study tests whether adding electroconvulsive therapy (ECT) to usual care can safely reduce severe agitation in people with moderate to severe dementia, including Alzheimer's and other types. About 50 participants will receive ECT plus their regular care. The goal is to see i…

This study tests whether a natural brain chemical called allopregnanolone can safely slow or reverse memory loss in Alzheimer's disease. About 100 people aged 55-80 with mild to moderate Alzheimer's will receive either the drug or a placebo for several months. The main goal is to…

This study is testing whether a blood test (Quest AD-Detect) can help doctors identify Alzheimer's disease in patients aged 60-90 who are hospitalized with confusion or delirium. The goal is to see if the test can tell the difference between Alzheimer's and other causes of cognit…

This study tests whether levetiracetam, a seizure medication, can prevent epileptic seizures in adults over 40 with Down syndrome who also have Alzheimer's disease. 120 participants will receive either the drug or a placebo for 96 weeks. The goal is to see if the drug can stop se…

This study tests if combining a medication (methylphenidate) with a type of non-invasive brain stimulation can reduce apathy in people with Alzheimer's disease or mixed dementia. Apathy, or lack of motivation, is a common and troubling symptom. The study will involve 12 participa…

This early study is testing whether a natural supplement called fisetin is safe for older adults with mild Alzheimer's disease or mild cognitive impairment. Only 5 participants will take the supplement, and researchers will closely watch for any side effects. This is a very small…