ACUTE LYMPHOCYTIC LEUKEMIA

This study tests an experimental oral drug called LP-118 in up to 100 adults with blood cancers like leukemia, lymphoma, or multiple myeloma that have come back or not responded to other treatments. The main goals are to find the safest dose and see if the drug can shrink tumors …

This study tests a new treatment for children and young adults (ages 3-39) with B-cell cancers like leukemia or lymphoma that have come back after standard therapy. The treatment uses a patient's own immune cells, which are modified in a lab to target two cancer proteins (CD19 an…

This study tests the safety and effectiveness of the drug ponatinib in children aged 1 to under 18 with advanced leukemias, lymphomas, or solid tumors that have come back or not responded to other treatments. The goal is to see if ponatinib can shrink or control the cancer. About…

This study tests a new immune therapy for people with advanced B-cell lymphoma or leukemia that has returned or not responded to standard treatment. Researchers take a patient's own T-cells, add a special receptor (CAR) that targets the CD19 protein on cancer cells, and give them…

This study tests whether using stem cells from both a half-matched family donor and a cord blood donor can improve survival for people with high-risk blood cancers like leukemia or myelodysplastic syndromes. About 36 participants will receive the transplant and be followed for up…

This study tests a new type of CAR-T cell therapy for adults with B-cell acute lymphoblastic leukemia that has come back or not responded to treatment. The therapy uses donor immune cells that are modified to better target and kill cancer cells while reducing side effects like gr…

This study is gathering basic health and survival information from 2000 people who are getting a stem cell transplant for blood cancers or immune diseases. The goal is to build a database that doctors can use to improve care and answer future questions. No experimental treatments…

This study looks at how the body processes venetoclax when the tablets are crushed and mixed into a liquid for children and young adults with blood cancers like leukemia or lymphoma. About 30 participants who already take venetoclax this way will have their blood levels measured.…

This study is testing whether a special PET scan called 18F FLT can detect signs of leukemia or related blood cancers after treatment. About 60 people aged 4 to 80 with relapsed or hard-to-treat leukemia or myeloma will get the scan before and after therapy. The goal is to see if…