Young-onset Parkinson disease
MONDO:0017279A form of Parkinson disease (PD) characterized by an age of onset between 21-45 years, rigidity, painful cramps followed by tremor, bradykinesia, dystonia, gait complaints and falls, and other non-motor symptoms. A slow disease progression and a more pronounced response to dopaminergic therapy are also observed in most YOPD forms.
Also known as: YOPD, early-onset Parkinson disease, early-onset Parkinson's disease
23 clinical trials for this condition and its sub-types, 9 tagged with Young-onset Parkinson disease itself.
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Sub-types of Young-onset Parkinson disease
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Parkinson disease 10 0 trials
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Parkinson disease 12 0 trials
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Early-onset Parkinson disease 20 0 trials
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Juvenile-onset Parkinson disease 0 trials
3 sub-types
- Kufor-Rakeb syndrome 0 trials Sub-types →
- Parkinson disease 19B, early-onset 0 trials
- Juvenile onset Parkinson disease 19A 0 trials
Most studied deeper sub-types
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Zapping the brain without surgery: a new hope for Parkinson's?
Disease control By invitation onlyThis study tests a noninvasive technique called temporal interference stimulation (TIS) to see if it can improve motor symptoms in people with Parkinson's disease and related conditions. Participants receive both active and sham stimulation in a random order, with each session la…
Sponsor: Ruijin Hospital • Aim: Disease control
Last updated Jul 15, 2026 00:00 UTC
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Parkinson's vaccine trial aims to slow disease progression
Disease control OngoingThis study tests a vaccine called ACI-7104.056 in 150 people with early-stage Parkinson's disease. The goal is to see if it is safe and helps the body fight a protein linked to Parkinson's. Participants must already be on stable low-dose levodopa. This is not a cure, but may help…
Phase 2 • Sponsor: AC Immune SA • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
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Heart scan may spot hidden brain disease
Diagnosis By invitation onlyThis study tests whether a special heart scan using a radioactive drug called 123I-MIBG can help identify Lewy body disease, a type of dementia that also affects movement and sleep. Researchers will compare scan results with clinical diagnoses in 50 people who have conditions lik…
Phase 4 • Sponsor: Mayo Clinic • Aim: Diagnosis
Last updated Aug 01, 2026 00:00 UTC
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New PET scan could slash radiation by 100x
Diagnosis By invitation onlyThis study tests a new PET imaging technique that uses 10 to 100 times less radiation than standard scans. Researchers will inject 200 healthy volunteers and patients with a radioactive tracer and use a high-sensitivity scanner to see if image quality remains good enough for dete…
Phase 2 • Sponsor: Akiva Mintz • Aim: Diagnosis
Last updated Jun 27, 2026 12:23 UTC
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Scientists hunt for clues to diagnose Parkinson's earlier
Knowledge-focused OngoingThis study aims to identify biomarkers—biological clues in the body—that can help distinguish between Parkinson's disease and similar conditions like progressive supranuclear palsy and multiple system atrophy. Researchers will follow people with early-stage parkinsonism and healt…
Sponsor: Non-profit organization for scientific research in Parkinson's disease and related disorders • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC