Young-onset Parkinson disease
MONDO:0017279A form of Parkinson disease (PD) characterized by an age of onset between 21-45 years, rigidity, painful cramps followed by tremor, bradykinesia, dystonia, gait complaints and falls, and other non-motor symptoms. A slow disease progression and a more pronounced response to dopaminergic therapy are also observed in most YOPD forms.
Also known as: YOPD, early-onset Parkinson disease, early-onset Parkinson's disease
23 clinical trials for this condition and its sub-types, 9 tagged with Young-onset Parkinson disease itself.
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Sub-types of Young-onset Parkinson disease
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Parkinson disease 10 0 trials
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Parkinson disease 12 0 trials
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Early-onset Parkinson disease 20 0 trials
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Juvenile-onset Parkinson disease 0 trials
3 sub-types
- Kufor-Rakeb syndrome 0 trials Sub-types →
- Parkinson disease 19B, early-onset 0 trials
- Juvenile onset Parkinson disease 19A 0 trials
Most studied deeper sub-types
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Brain gene therapy aims to boost dopamine in young Parkinson's patients
Disease control Not yet recruitingThis early-stage trial tests a gene therapy called AAV2-hAADC in 9 adults with young-onset Parkinson's disease. The therapy delivers a gene directly to two brain regions (putamen and caudate) to help convert levodopa into dopamine more efficiently. The main goal is to check safet…
Phase 1 • Sponsor: Krzysztof Bankiewicz • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
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Can a new pill slow Parkinson's symptoms?
Disease control Not yet recruitingThis clinical trial is testing an experimental medication called TJ0113 in people with early-onset Parkinson's disease. The study aims to see if TJ0113 can improve movement symptoms compared to a placebo. About 300 participants will take either TJ0113 or a placebo for 26 weeks, f…
Phase 3 • Sponsor: Hangzhou PhecdaMed Co., Ltd. • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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Could stem cells ease Parkinson's symptoms? new trial launches
Disease control Not yet recruitingThis study tests two types of stem cell treatments for people with Parkinsonism, a condition that causes movement and non-movement problems. The goal is to see if these treatments are safe and can improve symptoms like tremors, stiffness, and mood changes. About 120 adults aged 4…
Phase 2 • Sponsor: Biocells Medical • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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Could zapping the spine steady blood pressure in Parkinson's?
Disease control Not yet recruitingThis study tests whether spinal cord stimulation can help people with Parkinson's disease who experience sudden drops in blood pressure when standing up. Forty participants will receive either an implanted stimulator or a non-invasive version. The goal is to see if the treatment …
Sponsor: Ruijin Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
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Scientists launch 5-year watch on rare genetic Parkinson's to unlock disease secrets
Knowledge-focused Not yet recruitingThis study follows 70 people with PRKN- or PINK1-linked Parkinson's disease, as well as those with typical Parkinson's and healthy volunteers, over 5 years. Researchers will track movement, thinking, and mood symptoms, and collect blood, urine, and optional spinal fluid or muscle…
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Sep 20, 2026 00:00 UTC