X-linked spermatogenic failure 1

MONDO:0056795

A cause of male infertility characterized by X-linked inheritance in which only Sertoli cells (cells that nurture the immature sperm) line the seminiferous tubules (tubes inside the testicles where sperm develop) and there are not any sperm cells present in the seminiferous tubules.

Also known as: Del Castillo syndrome, Germinal cell aplasia, SPGFX1, Sertoli cell-only syndrome, spermatogenic failure, X-linked, type 1

3 clinical trials for this condition and its sub-types, 0 tagged with X-linked spermatogenic failure 1 itself.

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↑ Spermatogenic failure (12)

Including sub-types (3) Tagged with X-linked spermatogenic failure 1 (0)

Trials to join now! 1 Not yet recruiting 2

Scientists probe gene behind male infertility and cystic fibrosis

Knowledge-focused Recruiting now

This observational study aims to understand how the CFTR gene is regulated in epididymal cells, which may help explain male infertility linked to cystic fibrosis. Researchers will collect leftover tissue samples from 20 men already scheduled for surgery. No extra procedures are n…

Sponsor: University Hospital, Brest • Aim: Knowledge-focused

Last updated Jun 27, 2026 11:03 UTC

X-linked spermatogenic failure 1

Where it sits in the disease tree

Scientists probe gene behind male infertility and cystic fibrosis