Wild type ABeta2M amyloidosis

This study tests whether starting haemodialysis with fewer sessions per week (twice instead of the standard three times) can help preserve patients' remaining natural kidney function. New dialysis patients who still have some kidney function are randomly assigned to either standa…

This study tested an automated insulin delivery system (a smart pump) in 15 adults with type 1 or type 2 diabetes who also had advanced kidney disease or were on dialysis. Participants used the system for 8 weeks, then switched to their usual care for another 8 weeks. The goal wa…

This study tested a drug called MCI-196 in 245 adults on dialysis who have high phosphate levels, a common problem in advanced kidney disease. After a 4-week washout and 12-week dose adjustment, patients were randomly assigned to continue MCI-196 or switch to a placebo for 4 week…

This study tested the long-term safety of a drug called MCI-196 (Colestilan) in 116 adults with stage 5 chronic kidney disease who are on dialysis and have high phosphorus levels. Participants took flexible doses of the drug for 52 weeks. The main goal was to see how many side ef…

This Phase 3 trial tested MCI-196, a drug that binds phosphorus and lowers cholesterol, in 642 adults on dialysis with chronic kidney disease. Participants received either MCI-196 or a placebo for 12 weeks. The goal was to see if the drug could safely reduce both serum phosphorus…

This study tested the long-term safety of a drug called MCI-196 in 632 adults with chronic kidney disease on dialysis who have high phosphorus levels. Participants took the drug for up to 52 weeks to see how it affected their phosphorus and cholesterol. The goal was to help contr…

This Phase 3 trial tested a new drug called AP301 in 474 Chinese adults on dialysis who had high phosphorus levels. Participants took AP301, a low dose of AP301, or the standard drug sevelamer carbonate with meals. The main goal was to see how well AP301 lowers phosphorus compare…

This trial investigates whether applying a heated pack to the arm for 5 or 10 minutes before inserting a dialysis needle can reduce pain in people with an arteriovenous fistula. About 51 adults on hemodialysis will be randomly assigned to receive heat for 5 minutes, 10 minutes, o…

This study looked at 157 women with breast cancer who had a mastectomy. It compared two ways to drain fluid after surgery: active drainage (using suction) and passive drainage (gravity). The goal was to see which method led to less fluid buildup (seroma), shorter drain time, and …

This study tested whether lowering the temperature of the dialysis fluid from 36.5°C to 36°C could reduce the tiredness patients often feel after dialysis. Fifty-seven adults on maintenance hemodialysis received three sessions of 'cold dialysis' over one week. Researchers measure…

This study tested a communication tool called 'Best Case/Worst Case' for older adults with advanced kidney disease. Doctors were trained to discuss best, worst, and most likely outcomes for treatment options. The goal was to see if this approach helps patients receive more pallia…

This study looked at 60 adults on long-term dialysis to see if the schedule of dialysis sessions affects blood flow to the legs. Some patients did standard 4-hour sessions three times a week, while others did shorter 2-hour sessions six times a week. The goal was to find out whic…

This study aimed to find out how often people in Reunion Island start dialysis as an emergency and what social or medical factors lead to that. Researchers followed 233 adult patients beginning dialysis at local centers. The goal was to gather information to improve care and redu…

This study looked at 167 adults with chronic kidney disease on either hemodialysis or peritoneal dialysis to compare their blood levels of calcium, phosphorus, and other minerals linked to bone health. The goal was to see if one dialysis method is associated with fewer mineral an…