Vulvar lichen sclerosus
MONDO:0006491A chronic inflammatory disorder of unknown etiology that affects the vulva. It is characterized by the development of white elevated plaques in the vulva. Histologically there is marked subepithelial fibrosis. Clinical manifestations include pruritus, dysuria, and dyspareunia.
Also known as: lichen sclerosus et atrophicus of mammalian vulva, mammalian vulva lichen sclerosus et atrophicus, vulvar lichen sclerosus
17 clinical trials for this condition and its sub-types, 15 tagged with Vulvar lichen sclerosus itself.
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Laser zaps away lichen sclerosus symptoms in new trial
Disease control Recruiting nowThis study tests a fractional 2940 nm laser to treat lichen sclerosus lesions in 50 women aged 18 and older. The laser aims to reduce symptoms like itching, burning, and painful intercourse by removing damaged tissue and promoting healing. Researchers will check tissue samples 16…
Sponsor: Sciton • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New combo treatment tested for painful skin condition
Disease control Recruiting nowThis study tests whether adding a special radiofrequency treatment to standard steroid cream works better than steroid cream alone for women with vulvar lichen sclerosus, a chronic skin condition causing itching, pain, and discomfort. About 68 women of reproductive age will be ra…
Sponsor: Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Could a common arthritis drug ease a devastating skin condition?
Disease control Recruiting nowThis study tests whether methotrexate, a drug used for arthritis, can help women with severe vulvar lichen sclerosus that hasn't improved with standard steroid creams. Twelve women will receive weekly injections of methotrexate for 12 months. The goal is to see if symptoms and sk…
Phase 2 • Sponsor: Clinica Dermatologica Arbache ltda • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Laser may offer new hope for women with chronic vulvar condition
Disease control Recruiting nowThis study tests whether a fractional CO2 laser can reduce inflammation and symptoms like itching and pain in vulvar lichen sclerosus, a chronic skin condition. Forty women who have not been treated before will receive either standard clobetasol ointment or three laser sessions. …
Sponsor: Universidade Federal do Rio de Janeiro • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC
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Laser vs. steroid cream: new hope for vulvar lichen sclerosus?
Disease control Recruiting nowThis study compares a laser treatment (Monalisa Glide) to a standard steroid cream (clobetasol) for keeping vulvar lichen sclerosus under control. 120 women who have already completed 12 weeks of steroid treatment will receive either three laser sessions or continue using the cre…
Sponsor: Kantonsspital Winterthur KSW • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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New gel dressing aims to ease vaginal discomfort for thousands of women
Symptom relief Recruiting nowThis study is testing a new gel dressing for women with vaginal atrophy, lichen sclerosus, or similar vulvar skin conditions. About 2000 adult women will use the gel and report their symptoms and quality of life over 12 months. The goal is to see if the gel safely reduces discomf…
Sponsor: Stratpharma AG • Aim: Symptom relief
Last updated Jun 27, 2026 09:06 UTC