Vitiligo

Researchers are testing an experimental oral drug called VC005 in teenagers aged 12 to 17 who have non-segmental vitiligo, a condition where patches of skin lose their color. The study measures how the drug moves through the body and checks for safety over up to 24 weeks of treat…

This early-phase study tests whether combining mesenchymal stem cells (MSCs) with specially engineered immune cells (CAR-T cells) is safe and can help control autoimmune diseases. About 30 adults with established autoimmune conditions will receive the treatment and be monitored f…

This study tests whether specially engineered immune cells, called CAR-T cells, can safely treat autoimmune diseases. The cells are designed to target and suppress B cells, which play a key role in many autoimmune conditions. The trial involves 30 adults and focuses on safety and…

This early-stage trial tests clonal fetal mesenchymal stem cells (cfMSCs) in 100 people with severe immune-related disorders or tissue damage. The goal is to see if the cells are safe and can reduce symptoms. Participants have no other treatment options left.

This study tests two surgical techniques to treat stable white patches on the skin that are not caused by vitiligo. Both methods involve transplanting the patient's own skin cells, followed by laser therapy to boost color return. Twenty-two adults will each receive both treatment…

This phase 2a trial tests whether a daily pill called ACT-777991 can help return color to the face of adults with non-segmental vitiligo. About 30 participants will take either the drug or a placebo for 24 weeks. Researchers will measure changes in skin color using a standard sco…

This early study tests an experimental drug called STR-P005 in people with autoimmune diseases that have come back or not improved with standard treatments. The drug is given through an IV in multiple doses. The main goal is to check safety and see how the body handles the drug. …

This study tests a new medicine called GR2301, given as shots under the skin, together with light therapy for people with vitiligo (a condition that causes white patches on the skin). The trial has two parts: first, finding the right dose, then testing how well it works. About 11…

This study tests whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to standard narrowband UVB light treatment can help restore skin color in people with vitiligo. Five adults with non-segmental vitiligo will receive UVB twice a week for 24 …

This early study tests a new drug called STR-P005 in 18 people with autoimmune diseases that have not responded to standard treatments. The main goal is to check safety and find the best dose. Participants receive the drug by infusion in different schedules, and researchers will …

This study tests a cream called ruxolitinib on children aged 2 to 11 with a common type of vitiligo (white patches on skin). The goal is to see if the cream can safely bring back skin color over 24 weeks. About 20 children will apply the cream daily and visit the clinic for check…

This study tests an experimental pill called LW402 in 180 adults with non-segmental vitiligo, a condition that causes white patches on the skin. The pill works by blocking certain immune signals. Participants will take one of three doses or a placebo for up to 52 weeks to see if …

This study compares two treatments for stable vitiligo: microneedling with a topical solution (minoxidil) alone versus microneedling with the same solution plus narrow-band UV light therapy. Thirty adults with stable non-segmental vitiligo will be enrolled. The goal is to see if …

This study tests whether exosomes from umbilical cord stem cells can safely help restore skin color in adults with vitiligo. 96 participants with active or stable vitiligo will receive either exosome infusions or injections alongside standard light therapy and ointment. The goal …

This study tests whether adding a special cell secretion (called secretome) to standard light therapy helps restore skin color better in people with vitiligo. About 150 adults with stable vitiligo will receive either light therapy alone, or light therapy plus secretome applied th…

This study tests whether adding low-dose steroid pills to a standard vitiligo skin-cell transplant surgery helps prevent a pale ring around the treated area and improves overall skin color restoration. About 60 people with stable vitiligo will be randomly assigned to get surgery …

This study compares two treatments for generalized vitiligo: PUVA therapy (a light-based treatment) and the pill Tofacitinib. Researchers will enroll 64 adults with stable vitiligo covering more than 10% of their body. The goal is to see which treatment works better and is safer …

This study tests whether surgically removing the central mole (halo nevus) in people with vitiligo leads to better skin color restoration than using medication alone. Sixty participants aged 6 to 45 will be randomly assigned to either have the mole removed plus standard treatment…

This study compares two ways of delivering methotrexate to treat vitiligo patches: using a low-intensity electric current (iontophoresis) versus a standard gel. Thirty adults with stable vitiligo will be randomly assigned to one of the two treatments for 8 weeks. Researchers will…

This study tests whether blood samples collected at home using small capillary devices, like finger pricks, give the same results as traditional blood draws from a vein. Researchers will compare both methods in about 1,000 people with chronic conditions such as kidney disease, au…

This trial investigates whether annual re-screening for tuberculosis infection using a blood test (IGRA) can prevent active TB in people with autoimmune rheumatic diseases who are taking biologic or immunosuppressive medications. Participants who initially test negative for TB ar…

This study tests whether a single dose of amoxicillin before a simple tooth extraction can prevent infections in people with autoimmune rheumatic diseases who are on immune-suppressing medications. Researchers will compare infection rates between those who get the antibiotic and …

This study tests whether applying citric acid during a procedure to remove dark gum pigmentation leads to better-looking results and faster healing. Adults aged 18 to 50 with natural dark gums will receive either standard depigmentation or depigmentation plus acid. The researcher…

This study creates a UK-wide registry for people with vitiligo, a skin condition causing white patches. It will track the safety and effectiveness of current treatments in up to 30 patients. The goal is to improve long-term care by collecting real-world data from dermatologists.

This observational study aims to collect and analyze data from up to two million patients with dermatologic conditions like vitiligo, atopic dermatitis, alopecia areata, and hidradenitis suppurativa, as well as their healthcare providers. By reviewing treatment patterns, outcomes…

This observational study aims to map the immune and molecular profiles of people with inflammatory skin conditions, including genetic forms like epidermolysis bullosa. By comparing these profiles to those of healthy individuals, researchers hope to identify unique signatures that…

This study will test a new way to offer vaccines to vulnerable patients—those with chronic diseases or weakened immune systems—during hospital visits. Researchers will see if offering, prescribing, and giving vaccines in the hospital increases how many people get vaccinated. The …

This study will collect existing medical records from about 20,000 people aged 12 and older in Italy who have one of five inflammatory skin conditions: psoriasis, atopic dermatitis, vitiligo, alopecia areata, or hidradenitis suppurativa. Researchers want to describe who gets thes…

This study will measure 12 immune-signaling proteins (cytokines) in the blood of 125 people with vitiligo and healthy volunteers. The goal is to create a model that can predict when the disease will become active and how well a patient will respond to treatment. Currently, doctor…