Vascular malformation

This phase 2 trial tests a new treatment called bleomycin electrosclerotherapy (BEST) for low-flow vascular malformations—abnormal clusters of blood or lymph vessels. The approach combines an injected drug (bleomycin) with brief electrical pulses to make the drug work better. Res…

This phase 2 trial tests the drug everolimus in 67 people with vascular anomalies (abnormal blood vessels) that haven't responded to standard treatments. The goal is to shrink the lesions and improve symptoms. Participants take everolimus daily for 6 months, with doses adjusted b…

This study tests a minimally invasive procedure called microwave ablation to treat abnormal blood vessel clusters (vascular malformations) that cause pain and swelling. 150 patients will receive one session of this heat-based treatment, guided by ultrasound. Researchers will trac…

This early-phase trial tests a new nasal ointment called TOR-582, which contains sirolimus, in 27 adults with hereditary hemorrhagic telangiectasia (HHT) who have frequent nosebleeds. Participants apply the ointment inside their nostrils twice daily for 12 weeks, with different s…

This study gathers real-world data from medical records of patients with complex vascular anomalies treated with targeted therapies like mTOR inhibitors, MEK inhibitors, or PI3K inhibitors. Researchers will look at patient characteristics, treatment patterns, and side effects acr…

This study looks at how a PICC line (a thin tube placed in a vein for long-term medicine) affects the health of the vein wall. Researchers will measure vein thickness before and after the tube is removed in 80 adults who need a PICC. They will also test a special system that help…