Tongue disorder

This study tested whether a lower dose of radiation therapy, with or without the chemotherapy drug cisplatin, can effectively treat advanced oropharyngeal (throat) cancer in patients who are non-smokers. The trial enrolled 316 people with p16-positive cancer, a type linked to HPV…

This phase II trial tested whether adding sorafenib to cetuximab works better than cetuximab alone for patients with advanced head and neck cancer that has come back or spread. Fifty-five adults with various types of head and neck cancer took part. The study measured how long pat…

This completed trial compared two surgical techniques—frenotomy and frenectomy—for treating high frenum attachment in 46 healthy, non-smoking adults. The goal was to see which procedure leads to less relapse and less pain. Participants were randomly assigned to one of the two sur…

This study looked at whether giving radiation therapy after surgery can prevent early-stage oral cancer from coming back. It included 392 patients with tumors at least 5mm thick. Half received radiation, half were just watched. The main goal was to see if radiation reduced local …

This study tested whether a second round of treatment with tiny radioactive seeds (DaRT) could safely shrink or control skin, mouth, or soft tissue cancers that came back after the first treatment. Only 2 people took part, and researchers measured tumor response and side effects.…

This phase II trial tested whether adding the targeted drug cetuximab to standard chemotherapy and radiation could help prevent head and neck cancer from coming back after surgery. The study enrolled 53 patients with certain high-risk features. The main goal was to see how many p…

This phase 3 trial tested whether giving a special nutritional supplement (immunonutrition) before and after surgery could reduce infections in 311 patients with head and neck cancer. Participants were randomly assigned to one of three nutrition regimens. The main goal was to see…

This study tested a new diagnostic method (mass spectrometry) to detect Lyme disease bacteria in skin biopsies from 84 people with early Lyme rash (erythema migrans). The new method was compared to standard PCR and culture tests. The goal was to see if the new technique could ide…

Researchers compare two surgical techniques for rebuilding the tongue after cancer removal: the submental island pedicled flap, taken from under the chin, and the radial forearm free flap, taken from the arm. Twenty-eight adults with tongue cancer that requires partial or total r…

Researchers are studying blood and tumor tissue from people with squamous cell cancer of the larynx, pharynx, or oral cavity who have no history of smoking, heavy drinking, or workplace exposure to substances like asbestos or wood dust. The goal is to learn how DNA changes and bi…

This study tested whether clean, lab-bred ticks could find leftover Lyme bacteria in people who had been treated with antibiotics. 45 participants, including those with recent or past Lyme disease and healthy volunteers, had ticks placed on their skin for a few days. The goal was…

This study looked at 100 full-term newborns with tongue-tie to see if a simple procedure called frenotomy (clipping the tight band under the tongue) helps them breastfeed longer. Researchers measured suction strength before and after the procedure and tracked breastfeeding for 6 …