Tetralogy of fallot
MONDO:0008542Tetralogy of Fallot is a congenital cardiac malformation that consists of an interventricular communication, also known as a ventricular septal defect, obstruction of the right ventricular outflow tract, override of the ventricular septum by the aortic root, and right ventricular hypertrophy.
Also known as: tetralogy of fallot, ventricular septal defect with pulmonary stenosis or atresia, dextraposition of aorta, and hypertrophy of right ventricle, Fallot tetralogy, TOF, tetralogy of FALLOT
104 clinical trials for this condition and its sub-types, 34 tagged with Tetralogy of fallot itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →-
New heart valve passes safety check in 57 patients
Disease control CompletedThis study looked at the SAPIEN XT heart valve, which is placed through a thin tube (catheter) to fix a failed valve in the heart's right ventricle. Researchers wanted to confirm it is safe and works well. They enrolled 57 people with a narrowed or leaky heart valve conduit. The …
Sponsor: Edwards Lifesciences • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
-
Vitamin e shot may shield young hearts during complex surgery
Disease control CompletedThis study tested whether giving vitamin E (alpha-tocopherol) during heart surgery could reduce heart muscle damage in children with Tetralogy of Fallot, a birth defect. 58 children aged 1-10 years received either vitamin E or a placebo at the start of surgery. The main goal was …
Early phase 1 • Sponsor: Dr Cipto Mangunkusumo General Hospital • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
-
Cartoon therapy cuts pain in young heart patients
Symptom relief CompletedThis study tested if combining cartoon-watching with nurse interaction could ease pain in children after heart surgery. 70 kids aged 3-7 took part; half got standard pain care, and the other half also watched cartoons with a nurse. The goal was to see if this fun, non-drug approa…
Sponsor: Beijing Children's Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 08:08 UTC
-
Could a gentler breathing machine protect young hearts and brains after surgery?
Knowledge-focused CompletedChildren with congenital heart disease often need a breathing machine after surgery, and the pressure it creates can affect blood flow to the brain. This study compares conventional ventilation with NAVA, a mode that works with the child's own breathing signals, in 30 children re…
Sponsor: St. Justine's Hospital • Aim: Knowledge-focused
Last updated Sep 21, 2026 18:00 UTC
-
New MRI technique could sharpen heart monitoring for common birth defect
Knowledge-focused CompletedThis study tested whether a newer type of MRI called 4D flow can more accurately measure leakage in the pulmonary valve and heart chamber size in people born with tetralogy of Fallot who had corrective surgery. Researchers compared 4D flow MRI with standard 2D MRI in 21 patients …
Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC
-
MRI scans may reveal best time for heart valve surgery
Knowledge-focused CompletedThis study looked at 11 people with a repaired heart condition called tetralogy of Fallot who needed a new pulmonary valve. Researchers used MRI scans to measure heart muscle stiffness (fibrosis) and how well the heart pumped during rest and exercise. The goal was to see if these…
Sponsor: Assistance Publique Hopitaux De Marseille • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:31 UTC
-
Could an ultrasound replace MRI for heart monitoring?
Knowledge-focused CompletedThis study tested whether using a contrast dye during 3D ultrasound can accurately measure the size and function of the right heart chamber in people who had surgery for congenital heart disease. 25 participants received an injection of Lumason (an ultrasound contrast agent) and …
Phase 1/2 • Sponsor: Nemours Children's Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:24 UTC
-
New belt may help doctors fine-tune breathing machines for tiny lungs
Knowledge-focused CompletedThis study tested whether a special belt that creates images of the lungs (Electrical Impedance Tomography) can safely help doctors choose the best pressure settings on a breathing machine for infants under 3 years old. The study included 14 children with various serious conditio…
Sponsor: Papa Giovanni XXIII Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:09 UTC
-
3D hearts and AR boost med student learning in heart defect study
Knowledge-focused CompletedThis study tested whether 3D-printed heart models or augmented reality (AR) help first-year medical students understand two rare heart defects better than traditional slide lectures. 26 students took a quiz before and after learning with one of the three methods. The goal was to …
Sponsor: Case Western Reserve University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC