TCR-alpha-beta-positive T-cell deficiency

A non-severe combined immunodeficiency disorder manifesting with recurrent respiratory infections, candidiasis, diarrhea, and failure to thrive. Patients show a clear predisposition to herpes viral infections, and features of immune dysregulation, including hypereosinophilia, vitiligo, and alopecia areata. Other features include lymphadenopathy and hepatosplenomegaly. CD3+ T-cells express TCR- gamma|delta, but little or no TCR-alpha|beta.

Also known as: IMD7, TCR-alpha-beta+ T-cell deficiency, T-cell receptor-ALPHA/BETA deficiency, TCR-Alpha/Beta deficiency, immunodeficiency 7

2 clinical trials for this condition and its sub-types, 1 tagged with TCR-alpha-beta-positive T-cell deficiency itself.