Systemic mycosis

This Phase 3 trial tests a new drug called fosmanogepix against standard treatments for life-threatening Candida bloodstream or organ infections. About 450 adults will be randomly assigned to receive either fosmanogepix (first by IV, then as a pill) or the usual IV caspofungin fo…

This study is testing the antifungal drug posaconazole in infants under 2 years old who have a serious fungal infection. The goal is to find out how the drug moves through the body and what dose is safe. About 40 infants will receive the drug either through an IV or as a powder m…

This phase III trial is testing whether a single high dose (10 mg/kg) of liposomal amphotericin B can safely and effectively treat disseminated histoplasmosis, a serious fungal infection, in adults with AIDS. The standard treatment requires two weeks of daily infusions. The study…

This study tests a drug called olorofim in people recently diagnosed with coccidioidal meningitis, a rare fungal infection of the brain and spinal cord. About 12 participants will take olorofim and be followed for 6 months to see if it is safe and helps control the infection. The…

This trial tests whether a low dose of the antifungal drug liposomal amphotericin B can prevent invasive fungal infections in children aged 3 to 17 who have prolonged neutropenia (very low white blood cell counts) after cancer treatment or stem cell transplant. The drug is given …

This study tests whether faricimab (Vabysmo), an FDA-approved eye injection for other retinal diseases, can safely treat abnormal blood vessel growth in the eye caused by presumed ocular histoplasmosis syndrome. About 25 adults with this condition will receive an initial injectio…

This study compares a 7-day course of antifungal therapy to the standard 14-day course for children with uncomplicated candidemia (a blood infection caused by Candida fungus). About 420 children who have already received 7 days of treatment will be randomly assigned to stop or co…

This study tests whether using a patient's genetic profile to dose the antifungal drug voriconazole can help more patients reach the right drug levels faster. It will enroll 104 children and adults with blood cancer who have a fungal infection. Participants are randomly assigned …

This phase 2 trial tests whether the antifungal drug posaconazole can prevent serious fungal infections in 30 adults with blood cancer who are receiving a stem cell transplant from a donor. These patients are at high risk because of newer transplant methods. The study will check …

This Phase 1 trial tests a new radioactive tracer called [18F]-Fluorocellobiose ([18F]FCB) for PET/CT scans. The goal is to see if it can help find invasive mold infections in the body. The study includes healthy volunteers and people with known fungal infections. Participants re…

This study tests a new type of PET scan that uses a radioactive fungal component to see if it can light up areas of Aspergillus infection in the body. Ten adults with suspected invasive fungal infections will receive the scan. The goal is to see if this method can accurately loca…

This study looks at whether a low dose of the antifungal drug liposomal amphotericin B can prevent serious fungal infections in adults with blood cancers or who have had stem cell transplants and have a prolonged low white blood cell count (neutropenia). The trial enrolls 30 pati…

This study aims to understand why some people get severe or unusual fungal infections due to immune system problems. Researchers will collect blood, tissue, and other samples from up to 1,200 participants over 25 years. No new treatments are being tested; the goal is to learn mor…

This study looks at people with severe or hard-to-treat Valley Fever, a lung infection caused by a fungus found in the southwestern U.S. Researchers want to understand why some people get seriously ill by studying their immune systems and genetics. Up to 400 participants will giv…

This study is testing a new rapid diagnostic device called In-Dx to quickly identify infections and antibiotic resistance in emergency patients with suspected sepsis. Researchers will compare the device's results to standard lab cultures using stored samples from 2,500 patients. …

This study tracks 6000 stem cell transplant patients over 5 years to understand serious fungal infections. Researchers will collect data on diagnosis, treatment, and survival to create better prevention and care guidelines. The goal is to improve long-term outcomes for transplant…

This study looks at how the immune system responds in critically ill patients with severe abdominal infections. Researchers want to understand why some patients develop a serious fungal infection while others do not. They will measure a specific immune marker (HLA-DR) in 100 adul…

This study monitors the immune system of 20 adults with serious mold infections (like Aspergillus) to see how their T cells respond. The goal is to find out which patients might benefit from adding immunotherapy to standard antifungal drugs. Researchers will measure immune checkp…