Synovium disorder

This study tests an investigational drug called emactuzumab for people with a rare joint tumor (TGCT) that can't be removed surgically. About 128 participants will receive either the drug or a placebo to see if it shrinks tumors and improves joint function. The goal is to offer a…

This phase 3 trial tests the drug pexidartinib in 40 adults with tenosynovial giant cell tumor (TGCT), a rare, non-cancerous growth in joints that causes pain and limits movement. The study focuses on people whose tumors are severe and cannot be helped by surgery. Researchers are…

This study tests a drug called vimseltinib in people with a rare joint tumor (tenosynovial giant cell tumor, or TGCT) and advanced solid tumors. The drug blocks a protein that helps these tumors grow. The trial has two phases: first, finding the safest dose, then expanding to see…

This Phase 3 trial tests whether the drug Pimicotinib (ABSK021) can shrink tumors and improve symptoms in people with tenosynovial giant cell tumor (TGCT), a rare, non-cancerous growth in joints that cannot be surgically removed. About 94 adults will receive either the drug or a …

This study tests whether a once-weekly medication (efanesoctocog alfa) can improve or prevent joint damage in 37 people with moderate or severe hemophilia A. Participants receive the drug for 12 months, and doctors use ultrasound and MRI to check joint health. The goal is to see …

This phase 3 trial tests vimseltinib, an oral drug, for tenosynovial giant cell tumor (TGCT) when surgery isn't possible. About 123 adults with symptomatic TGCT will receive either vimseltinib or a placebo for 24 weeks, then all can get the drug. The main goal is to see if the dr…

This study looks at the best way to treat partial rotator cuff tears in people who also have stiff shoulders. Half of the 80 participants will have early surgery, while the other half will follow a structured rehab program with the option of surgery later if needed. The goal is t…

This study tests a new injection called NEMO-103 to see if it makes shoulder MRI pictures clearer for diagnosing problems like torn tendons or cartilage. About 85 adults with known or suspected shoulder issues will get both a regular MRI and one with the injection. The goal is to…

Researchers are comparing three ways to treat shoulder stiffness: physical therapy alone, the ERMI Shoulder Flexionater stretch device alone, and the device plus physical therapy. The trial includes people with frozen shoulder (adhesive capsulitis), people with stiffness after sh…

This study tests whether an extended-release steroid injection (Zilretta) given during knee meniscus surgery can reduce pain and inflammation in people with osteoarthritis. 150 adults aged 40 and older are enrolled. Researchers will measure knee pain scores and inflammatory marke…

This study tests two physical therapy techniques for frozen shoulder (adhesive capsulitis). About 42 adults aged 40-60 will receive either Gong's mobilization alone or with an added scapular lift. The goal is to see which method better improves shoulder movement, reduces pain, an…

This trial tests whether a rehabilitation program that exercises the entire leg — from foot to hip — can improve balance, reduce pain, and restore function better than standard tendon-focused exercises in people with chronic Achilles tendinopathy. Fifty adults aged 18 to 45 with …

This study tests a single injection called 4P004 for people with knee osteoarthritis and synovitis (inflammation). About 129 adults aged 40-80 will receive either the injection or a placebo. The goal is to see if it reduces daily knee pain and improves function over 12 weeks.

This study looks at whether adding neck and upper back mobility exercises to standard care can improve posture, reduce shoulder pain, and increase range of motion in people with frozen shoulder. Researchers will enroll 40 adults aged 20 to 70 who have been diagnosed with frozen s…

This study combines artificial intelligence with ultrasound imaging to better understand and treat frozen shoulder (adhesive capsulitis). Researchers will compare three different ultrasound-guided injection techniques in 192 participants to see which one best reduces pain and imp…

This study tests whether dronabinol, a drug made from cannabis, can help control pain after knee arthroscopy. About 30 adults will take part to see if it reduces the need for opioid painkillers and causes fewer side effects. The results will help decide if larger studies are need…

This study tests a new physical therapy approach for people with frozen shoulder (stage 2 or 3). The technique combines specific stretches with shoulder mobilization. Researchers will measure improvements in shoulder movement and daily function. The trial is currently on hold.

This study looks at whether a treatment called pulsed radiofrequency (PRF) applied to a key shoulder nerve can help people with long-lasting shoulder pain that hasn't improved with standard treatments like painkillers or physical therapy. The study involves 60 adults with chronic…

This study looks at whether modified robbery exercises can help people with frozen shoulder who also have abnormal shoulder blade movement. About 63 adults aged 35 to 55 with shoulder pain for at least 3 months will be assigned to either the exercise group or a control group. Res…

This study tests whether a self-management program led by a physiotherapist can reduce pain and improve function in people with greater trochanteric pain syndrome (chronic hip pain). 110 adults aged 18-70 with hip pain for over 3 months will be randomly assigned to either the sel…

This study compares two treatments for frozen shoulder (adhesive capsulitis): Mulligan mobilization (a hands-on therapy) and shockwave therapy (sound waves). Sixty adults aged 40-60 with stiff, painful shoulders for at least 3 months will receive one of the treatments for 4 weeks…

This study reviews published research to compare surgical and non-surgical treatments for frozen shoulder (adhesive capsulitis), a painful condition that limits shoulder movement. By analyzing data from previous studies, the researchers hope to identify which approach works best …