Substance withdrawal syndrome
MONDO:0005567A substance-specific organic brain syndrome that follows the discontinuation of administration or use, or reduction in intake of a substance (including alcohol, prescribed medications and recreational drugs). Syndrome manifests with diverse, often painful physical and psychological symptoms, which include but not limited to intense drug craving, anxiety, depression, insomnia, nausea, perspiration, body aches, tremors, hallucinations, and convulsions.
Also known as: drug withdrawal, drug withdrawal syndrome, substance withdrawal, substance withdrawal disorder, substance withdrawal syndrome, withdrawal syndrome, withdrawal disorder
157 clinical trials for this condition and its sub-types, 30 tagged with Substance withdrawal syndrome itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Substance withdrawal syndrome
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Neonatal abstinence syndrome 18 trials
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Alcohol withdrawal 11 trials · 13 incl. sub-types
1 sub-type
- Alcohol withdrawal delirium 2 trials
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Baclofen withdrawal syndrome 0 trials
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Can a device replace pills for opioid withdrawal?
Disease control CompletedThis study tested a device called the Bridge, which uses mild electrical pulses to ease opioid withdrawal symptoms. 36 adults with opioid addiction were randomly assigned to get the active device, withdrawal medication (lofexidine), or a placebo. The goal was to see if the device…
Phase 2/3 • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Jun 27, 2026 13:05 UTC
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Can pomegranate seed oil cut infections in dementia patients?
Disease control CompletedThis study looked at whether giving pomegranate seed oil supplements for 24 weeks could help prevent urinary tract infections and pneumonia in people with advanced dementia who are in palliative care. It also checked if the supplement helped reduce or stop antipsychotic medicatio…
Sponsor: Panhellenic Federation of Alzheimer's Disease and Related Disorders • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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Patch could make opioid treatment start easier for pregnant women
Symptom relief CompletedThis study tests whether a buprenorphine patch can reduce withdrawal symptoms when pregnant women with opioid use disorder start sublingual buprenorphine treatment. Forty participants will receive either a real patch or a sham bandage during the initial withdrawal period. Researc…
Phase 3 • Sponsor: Washington University School of Medicine • Aim: Symptom relief
Last updated Sep 12, 2026 00:00 UTC
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New drug shows promise in calming opioid withdrawal
Symptom relief CompletedThis study tested a new medicine called BXCL501 to see if it can safely reduce the unpleasant symptoms people feel when they stop taking opioids. 225 adults with opioid use disorder took part. The medicine was given as a film under the tongue, and researchers measured withdrawal …
Phase 1/2 • Sponsor: BioXcel Therapeutics Inc • Aim: Symptom relief
Last updated Aug 13, 2026 00:00 UTC
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Herbal brew shows promise for easing withdrawal in small study
Symptom relief CompletedThis study tested a traditional Chinese herbal drink called Tiaozhong-Yiqi Decoction (TZYD) in 80 adults with substance withdrawal syndrome. Half took the herbal medicine twice daily for 3 months plus routine care, while the other half received only routine care. The goal was to …
Sponsor: Chongqing Jiangbei Hospital of Traditional Chinese Medicine • Aim: Symptom relief
Last updated Jun 27, 2026 12:24 UTC
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Opioid tapering trial aims to help chronic pain patients cut back
Symptom relief CompletedThis study tested whether slowly reducing prescribed opioids (tapering) can help people with long-term chronic pain use fewer painkillers without worsening their pain or quality of life. 140 adults on daily opioids for chronic non-cancer pain were randomly assigned to start taper…
Sponsor: Lund University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:09 UTC