Substance dependence
MONDO:0004938The psychological or physiological need to take a substance in order to experience its effects or to avoid the effects of its absence.
Also known as: dependence
1372 clinical trials for this condition and its sub-types, 15 tagged with Substance dependence itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Substance dependence
-
Drug dependence 14 trials · 1,284 incl. sub-types
10 sub-types
- Opiate dependence 545 trials Sub-types →
- Nicotine dependence 412 trials
- Cannabis dependence 218 trials
- Methamphetamine dependence 63 trials
- Cocaine dependence 51 trials
- Alcohol dependence 44 trials
- Hallucinogen dependence 1 trial
- Alcohol and nicotine codependence 0 trials
- Barbiturate dependence 0 trials
- Phencyclidine abuse 0 trials
Most studied deeper sub-types
-
Can Long-Acting injections stop stimulant psychosis from worsening?
Disease control CompletedThis study tested two long-acting injectable medications, aripiprazole and paliperidone, in 165 people who use stimulants and have psychosis. The goal was to see if these drugs could better manage psychosis and prevent progression to chronic schizophrenia compared to standard tre…
Phase 2/3 • Sponsor: The University of Hong Kong • Aim: Disease control
Last updated Jun 27, 2026 12:01 UTC
-
Brain zaps may curb meth cravings in small pilot trial
Disease control CompletedThis small pilot study tested whether a type of brain stimulation called transcranial magnetic stimulation (TMS) could help people with methamphetamine use disorder. Nineteen participants received daily TMS sessions for two weeks, then three times a week for two more weeks, while…
Sponsor: Ryan M. Carnahan • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
-
Exercise and music may ease drug cravings and depression in rehab
Symptom relief CompletedThis completed study looked at whether combining exercise with music can help people recovering from drug addiction. 92 adults in a Chinese rehab center were split into groups: exercise only, exercise with fast music, exercise with slow music, or a control group. Over six months,…
Sponsor: WEIPENG DUAN • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
-
Baltimore study investigates how neighborhoods shape drug habits
Knowledge-focused CompletedThis completed study looked at how a person's neighborhood environment might influence drug use, addiction, and whether they seek treatment. Over 1,600 adults from Baltimore took part, including people who never used drugs, past users, and current users. Researchers collected hea…
Sponsor: National Institute on Drug Abuse (NIDA) • Aim: Knowledge-focused
Last updated Sep 17, 2026 00:00 UTC