Staphylococcal infection

This study tests whether giving two IV antibiotics early, instead of one, can clear Staphylococcus aureus bloodstream infections faster and improve outcomes. About 300 hospitalized adults will be randomly assigned to receive either a single antibiotic or a combination of two. Onc…

This study tests whether giving a newborn a nasal microbiome transplant from their parent can increase the diversity of bacteria in the baby's nose. The goal is to see if this can help prevent infections like those caused by Staphylococcus aureus. The study involves 175 premature…

This study tests whether taking a 7-day course of oral antibiotics after hip or knee replacement surgery can prevent joint infections in patients at higher risk due to conditions like obesity, diabetes, or autoimmune disease. About 4,600 participants will receive one of three ant…

This phase II trial tests whether a fecal microbiota transplant (using donor stool) can help eliminate multidrug-resistant organisms (MDROs) from the gut of infected patients. 32 adults with resistant bacterial infections will receive the transplant plus standard antibiotics. The…

This early study tests whether transferring a parent's healthy nasal bacteria to their newborn can help prevent staph infections. Researchers will give the baby a nasal spray containing the parent's bacteria or a placebo, then monitor the baby's nose bacteria and safety. The stud…

This study investigates whether taking rifampicin for latent tuberculosis increases the risk of antibiotic resistance in Staphylococcus aureus bacteria that naturally live on the skin. Researchers will compare people treated with rifampicin to those treated with isoniazid, taking…

This study looks at how the immune system bounces back in people who survive a severe bloodstream infection caused by Staphylococcus aureus bacteria. Researchers are measuring specific immune markers, like HLA-DR on monocytes, to see if recovery differs between people with and wi…

This study looks back at medical records of about 5,000 people with a serious bloodstream infection caused by a common bacterium. Researchers compare two antibiotic treatments to see which one leads to better survival and fewer side effects. The goal is to find out if a newer opt…

This study looks at data from two previous clinical trials involving 369 patients with Staphylococcus aureus bloodstream infections. Researchers want to see if adding the antibiotic fosfomycin to standard care helps certain patient groups more than others. They will classify pati…