Stage I endometrioid carcinoma
MONDO:0004961Endometrial cancer is a cancer that arises from the endometrium (the lining of the uterus or womb).It is the result of the abnormal growth of cells that have the ability to invade or spread to other parts of the body. The first sign is most often vaginal bleeding not associated with a menstrual period. Other symptoms include pain with urination or sexual intercourse, or pelvic pain. Endometrial cancer occurs most commonly after menopause. In stage I, the cancer is only growing in the body of the uterus. It may also be growing into the glands of the cervix, but is not growing into the supporting connective tissue of the cervix.
2863 clinical trials for this condition and its sub-types, 16 tagged with Stage I endometrioid carcinoma itself.
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Could less be more? new trial tailors endometrial cancer treatment to tumor type
Disease control Recruiting nowThis phase II study is testing whether women with certain types of early-stage endometrial cancer can safely receive less aggressive treatment after surgery. The approach is guided by the tumor's molecular profile—either POLE-mutated or p53 wildtype/NSMP. Around 393 participants …
Phase 2 • Sponsor: Canadian Cancer Trials Group • Aim: Disease control
Last updated Sep 17, 2026 00:00 UTC
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Can one surgery treat endometrial cancer and obesity together?
Disease control Recruiting nowThis trial tests whether obese patients with endometrial cancer or a precancerous condition can safely undergo a hysterectomy and weight loss surgery at the same time. Researchers want to see if a fast-track referral process can get patients to surgery within 8 to 12 weeks of dia…
Sponsor: Dana-Farber Cancer Institute • Aim: Disease control
Last updated Sep 02, 2026 00:00 UTC
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New hormone combo aims to save fertility in early uterine cancer
Disease control Recruiting nowThis phase 2 trial tests whether a combination of a gonadotropin-releasing hormone agonist (triptorelin) and letrozole can achieve better complete response rates than standard hormone therapy (megestrol acetate or medroxyprogesterone acetate) in women with early-stage endometrial…
Phase 2 • Sponsor: Fudan University • Aim: Disease control
Last updated Jun 27, 2026 13:02 UTC
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Weight loss program may help women avoid hysterectomy and preserve fertility
Disease control Recruiting nowThis study tests whether adding a behavioral weight loss program to standard hormone therapy helps premenopausal women with obesity and early endometrial cancer or precancer keep their uterus and fertility. About 96 women will receive either the weight loss program plus hormone t…
Phase 2 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Ultrasound may spot endometriosis without surgery
Diagnosis Recruiting nowThis study tests whether a specific ultrasound measurement can reliably detect superficial endometriosis on the uterosacral ligaments. Researchers will compare ultrasound findings with laparoscopic surgery results in 64 women undergoing gynecological surgery. If a clear cutoff th…
Sponsor: Casa di Cura Dott. Pederzoli • Aim: Diagnosis
Last updated Jun 27, 2026 09:07 UTC
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New study aims to reduce leg swelling in endometrial cancer surgery
Symptom relief Recruiting nowThis study tests whether a less invasive lymph node procedure (sentinel mapping) can lower the risk of long-term leg swelling compared to standard lymph node removal. About 428 women with stage I endometrial cancer will be followed for 18 months after hysterectomy. The goal is to…
Phase 3 • Sponsor: NRG Oncology • Aim: Symptom relief
Last updated Aug 09, 2026 00:00 UTC
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New study aims to determine if less surgery is better for Early-Stage endometrial cancer
Knowledge-focused Recruiting nowThis study looks at whether removing only a few key lymph nodes (sentinel node biopsy) is better than removing no nodes at all in women with early-stage endometrial cancer. The goal is to see if this approach helps women return to normal activities faster and does not increase th…
Phase 3 • Sponsor: Queensland Centre for Gynaecological Cancer • Aim: Knowledge-focused
Last updated Sep 17, 2026 00:00 UTC
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Large study aims to pinpoint cancer return rates and swelling risks after treatment
Knowledge-focused Recruiting nowThis study is observing about 1,715 people with early-stage endometrial cancer to see how often the cancer comes back and how often lymphedema (swelling) happens after standard treatment. Participants will have regular check-ups for 36 months. The goal is to gather real-world dat…
Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Knowledge-focused
Last updated Aug 09, 2026 00:00 UTC
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Do tiny cancer cells in lymph nodes matter? new study aims to find out
Knowledge-focused Recruiting nowThis study is for people with a low-risk type of uterine cancer (endometrial cancer). Researchers want to see if finding very small groups of cancer cells (called isolated tumor cells) in the first lymph nodes near the tumor changes the chance of the cancer coming back. About 212…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC