Squamous cell carcinoma of penis
MONDO:0018352A squamous cell carcinoma arising from the penis. It occurs chiefly in the squamous epithelium of the glans, coronal sulcus, and foreskin. Etiologic factors include phimosis, lichen sclerosus, smoking, ultraviolet irradiation, history of warts or condylomas, and lack of circumcision. Human papilloma virus is present in a subset of penile squamous cell carcinomas. Patients may present with an exophytic or flat ulcerative mass in the glans or a large primary tumor with inguinal nodal and skin metastases. Morphologic variants include the basaloid carcinoma, warty (condylomatous) carcinoma, verrucous carcinoma, and sarcomatoid (spindle cell) carcinoma. (WHO, 2004)
Also known as: epidermoid carcinoma of penis, epidermoid carcinoma of the penis, epidermoid cell carcinoma of penis, epidermoid cell carcinoma of the penis, penile epidermoid carcinoma, penile epidermoid cell carcinoma, penile squamous car.(epidermoid), penile squamous carcinoma (epidermoid)
2776 clinical trials for this condition and its sub-types, 21 tagged with Squamous cell carcinoma of penis itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Squamous cell carcinoma of penis
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2 sub-types
- Basaloid carcinoma of the penis 0 trials
- Warty carcinoma of the penis 0 trials
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Penis carcinoma in situ 1 trial
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Papillary carcinoma of the penis 0 trials
2 sub-types
- Penis verrucous carcinoma 0 trials Sub-types →
- Warty carcinoma of the penis 0 trials
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Penis mixed squamous cell carcinoma 0 trials
Most studied deeper sub-types
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New hope for rare cancers: drug duo shows promise
Disease control OngoingThis phase II trial tests whether combining two drugs, atezolizumab and bevacizumab, can shrink rare solid tumors like appendix cancer, anal cancer, and mesothelioma. About 133 participants with various rare cancers will receive the drugs intravenously. The goal is to see if the …
Phase 2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Sep 16, 2026 00:00 UTC
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New drug cocktail shows promise for Hard-to-Treat urinary cancers
Disease control OngoingThis early-phase study tests a combination of two or three drugs (cabozantinib, nivolumab, and sometimes ipilimumab) in people with advanced genitourinary cancers that have spread. The main goals are to find the safest doses and understand side effects. About 152 adults with vari…
Phase 1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Sep 12, 2026 00:00 UTC
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Can adding chemotherapy before surgery beat penile cancer?
Disease control OngoingThis phase 3 trial tests whether giving chemotherapy or chemoradiotherapy before surgery improves survival for people with penile cancer that has spread to lymph nodes in the groin. Participants are randomly assigned to receive standard surgery alone, chemotherapy followed by sur…
Phase 3 • Sponsor: Institute of Cancer Research, United Kingdom • Aim: Disease control
Last updated Sep 02, 2026 00:00 UTC
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Immunotherapy drug avelumab takes on rare penile cancer
Disease control OngoingThis phase 2 trial tests whether avelumab, an immunotherapy drug, can shrink tumors in 25 people with advanced penile cancer who cannot take platinum chemotherapy or whose cancer worsened after it. Avelumab works by blocking a protein that helps tumors hide from the immune system…
Phase 2 • Sponsor: University Health Network, Toronto • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
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Immunotherapy duo takes on rare tumors
Disease control OngoingThis phase 2 trial is testing a combination of two immunotherapy drugs, nivolumab and ipilimumab, in 798 people with over 50 types of rare cancers. The goal is to see if these drugs can shrink tumors by helping the immune system attack cancer cells. Participants receive the drugs…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC