Squamous cell carcinoma
MONDO:0005096A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma.
Also known as: carcinoma, squamous cell, malignant, epidermoid carcinoma, epidermoid cell cancer, malignant epidermoid cell neoplasm, malignant epidermoid cell tumor, malignant epidermoid cell tumour, malignant squamous cell neoplasm, malignant squamous cell tumor
4392 clinical trials for this condition and its sub-types, 177 tagged with Squamous cell carcinoma itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Squamous cell carcinoma
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Head and neck squamous cell carcinoma 829 trials · 1,053 incl. sub-types
13 sub-types
- Pharyngeal squamous cell carcinoma 5 trials · 203 incl. sub-types Sub-types →
- Lip and oral cavity squamous cell carcinoma 21 trials · 157 incl. sub-types Sub-types →
- Laryngeal squamous cell carcinoma 72 trials · 77 incl. sub-types Sub-types →
- Nasal cavity and paranasal sinus squamous cell carcinoma 9 trials · 13 incl. sub-types Sub-types →
- Nasopharyngeal squamous cell carcinoma 12 trials
- Paranasal sinus squamous cell carcinoma 11 trials Sub-types →
- Nasal cavity squamous cell carcinoma 6 trials
- External ear squamous cell carcinoma 1 trial
- Conjunctival squamous cell carcinoma 0 trials
- Cornea squamous cell carcinoma 0 trials
- Lacrimal gland squamous cell carcinoma 0 trials
- Middle ear squamous cell carcinoma 0 trials
- Primary intraosseous squamous cell carcinoma 0 trials
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Esophageal squamous cell carcinoma 303 trials · 304 incl. sub-types
4 sub-types
- Esophageal adenosquamous carcinoma 3 trials
- Undifferentiated carcinoma of esophagus 1 trial
- Esophageal basaloid carcinoma 0 trials
- Esophagus verrucous carcinoma 0 trials
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Skin squamous cell carcinoma 149 trials · 156 incl. sub-types
9 sub-types
- Skin squamous cell carcinoma in situ 4 trials · 6 incl. sub-types Sub-types →
- Anal margin squamous cell carcinoma 4 trials
- Acantholytic squamous cell skin carcinoma 1 trial
- Clear cell squamous cell skin carcinoma 1 trial
- Sarcomatoid squamous cell skin carcinoma 1 trial
- Plantar verrucous skin carcinoma 0 trials
- Pseudovascular skin squamous cell carcinoma 0 trials
- Skin adenosquamous carcinoma 0 trials
- Skin basaloid carcinoma 0 trials
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Squamous cell lung carcinoma 65 trials · 145 incl. sub-types
2 sub-types
- Non-small cell squamous lung carcinoma 83 trials · 88 incl. sub-types Sub-types →
- Lung occult squamous cell carcinoma 0 trials
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Human papillomavirus-related squamous cell carcinoma 115 trials · 116 incl. sub-types
1 sub-type
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Colorectal squamous cell carcinoma 1 trial · 54 incl. sub-types
3 sub-types
- Squamous cell carcinoma of rectum 8 trials · 53 incl. sub-types Sub-types →
- Colorectal adenosquamous carcinoma 0 trials Sub-types →
- Squamous cell carcinoma of colon 0 trials Sub-types →
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Adenosquamous carcinoma 8 trials · 45 incl. sub-types
15 sub-types
- Cervical adenosquamous carcinoma 16 trials Sub-types →
- Pancreatic adenosquamous carcinoma 13 trials
- Adenosquamous lung carcinoma 5 trials
- Esophageal adenosquamous carcinoma 3 trials
- Endometrial adenosquamous carcinoma 2 trials
- Bartholin gland adenosquamous carcinoma 0 trials
- Adenosquamous breast carcinoma 0 trials
- Adenosquamous prostate carcinoma 0 trials
- Colorectal adenosquamous carcinoma 0 trials Sub-types →
- Gallbladder adenosquamous carcinoma 0 trials
- Gastric adenosquamous carcinoma 0 trials
- Liver adenosquamous carcinoma 0 trials Sub-types →
- Salivary gland adenosquamous carcinoma 0 trials
- Skin adenosquamous carcinoma 0 trials
- Thymic adenosquamous carcinoma 0 trials
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Cervical squamous cell carcinoma 36 trials · 40 incl. sub-types
7 sub-types
- Cervical adenosquamous carcinoma 16 trials Sub-types →
- Cervical basaloid carcinoma 0 trials
- Cervical keratinizing squamous cell carcinoma 0 trials
- Cervical lymphoepithelioma-like carcinoma 0 trials
- Cervical non-keratinizing squamous cell carcinoma 0 trials
- Cervical verrucous carcinoma 0 trials
- Microinvasive cervical squamous cell carcinoma 0 trials
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Metastatic squamous cell carcinoma 39 trials
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Squamous cell carcinoma of penis 21 trials · 29 incl. sub-types
5 sub-types
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Vulvar squamous cell carcinoma 22 trials
6 sub-types
- Bartholin gland squamous cell carcinoma 0 trials Sub-types →
- Vulva verrucous carcinoma 0 trials
- Vulvar basaloid squamous cell carcinoma 0 trials
- Vulvar keratinizing squamous cell carcinoma 0 trials
- Vulvar keratoacanthoma-like carcinoma 0 trials
- Vulvar non-keratinizing squamous cell carcinoma 0 trials
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Squamous cell carcinoma of pancreas 3 trials · 13 incl. sub-types
1 sub-type
- Pancreatic adenosquamous carcinoma 13 trials
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Bone squamous cell carcinoma 0 trials · 11 incl. sub-types
1 sub-type
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Squamous carcinoma in situ 5 trials · 10 incl. sub-types
3 sub-types
- Skin squamous cell carcinoma in situ 4 trials · 6 incl. sub-types Sub-types →
- Penis carcinoma in situ 1 trial
- Trachea carcinoma in situ 0 trials
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Vaginal squamous cell carcinoma 8 trials
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Bladder squamous cell carcinoma 5 trials
2 sub-types
- Bladder urachal squamous cell carcinoma 0 trials
- Bladder verrucous carcinoma 0 trials
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Basaloid squamous cell carcinoma 2 trials · 5 incl. sub-types
7 sub-types
- Anus basaloid carcinoma 3 trials
- Basaloid carcinoma of the penis 0 trials
- Cervical basaloid carcinoma 0 trials
- Esophageal basaloid carcinoma 0 trials
- Skin basaloid carcinoma 0 trials
- Thymic basaloid carcinoma 0 trials
- Vulvar basaloid squamous cell carcinoma 0 trials
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Gastric squamous cell carcinoma 4 trials
1 sub-type
- Gastric adenosquamous carcinoma 0 trials
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Papillary squamous carcinoma 1 trial · 4 incl. sub-types
2 sub-types
- Verrucous carcinoma 0 trials · 3 incl. sub-types Sub-types →
- Papillary carcinoma of the penis 0 trials Sub-types →
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Ovarian squamous cell carcinoma 2 trials
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Urethra squamous cell carcinoma 2 trials
1 sub-type
- Urethral verrucous carcinoma 0 trials
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Endometrial squamous cell carcinoma 0 trials · 2 incl. sub-types
1 sub-type
- Endometrial adenosquamous carcinoma 2 trials
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Scrotum squamous cell carcinoma 1 trial
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1 sub-type
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Ureter squamous cell carcinoma 1 trial
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Keratinizing squamous cell carcinoma 0 trials · 1 incl. sub-types
8 sub-types
- Acantholytic squamous cell skin carcinoma 1 trial
- Clear cell squamous cell skin carcinoma 1 trial
- Sarcomatoid squamous cell skin carcinoma 1 trial
- Cervical keratinizing squamous cell carcinoma 0 trials
- Large cell keratinizing variant squamous cell breast carcinoma 0 trials
- Pseudovascular skin squamous cell carcinoma 0 trials
- Skin basaloid carcinoma 0 trials
- Vulvar keratinizing squamous cell carcinoma 0 trials
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Gallbladder squamous cell carcinoma 0 trials
1 sub-type
- Gallbladder adenosquamous carcinoma 0 trials
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Prostate squamous cell carcinoma 0 trials
1 sub-type
- Adenosquamous prostate carcinoma 0 trials
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Renal pelvis squamous cell carcinoma 0 trials
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Sarcomatoid squamous cell carcinoma 0 trials
2 sub-types
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Squamous cell breast carcinoma 0 trials
4 sub-types
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2 sub-types
- Liver adenosquamous carcinoma 0 trials Sub-types →
- Squamous cell bile duct carcinoma 0 trials Sub-types →
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Thymus squamous cell carcinoma 0 trials
2 sub-types
- Thymic adenosquamous carcinoma 0 trials
- Thymic basaloid carcinoma 0 trials
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Trachea squamous cell carcinoma 0 trials
1 sub-type
- Trachea carcinoma in situ 0 trials
Most studied deeper sub-types
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Triple therapy aims to shrink head and neck tumors before surgery
Disease control Not yet recruitingThis study tests a combination of an experimental drug (ficerafusp alfa), an immunotherapy (pembrolizumab), and targeted radiation before surgery for people with advanced head and neck cancer that is HPV-negative. About 45 participants will receive these treatments over several w…
Phase 1/2 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Aug 15, 2026 00:00 UTC
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New skin patch could speed recovery after skin cancer removal
Disease control Not yet recruitingThis trial tests whether a new skin graft substitute (CAMP) plus standard wound care helps wounds heal faster after Mohs surgery for skin cancer compared to standard care alone. About 160 adults who have had Mohs surgery for a skin cancer will be randomly assigned to receive eith…
Phase 4 • Sponsor: BioLab Holdings • Aim: Disease control
Last updated Jul 12, 2026 00:00 UTC
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New combo aims to tame HPV throat cancer with fewer side effects
Disease control Not yet recruitingThis early-phase trial tests whether a new drug (ATRN-119) combined with a single, precise dose of radiation to the neck can safely and effectively treat early-stage HPV-positive throat cancer before surgery. About 35 participants will take the drug daily for 10 days and receive …
Phase 1/2 • Sponsor: Abramson Cancer Center at Penn Medicine • Aim: Disease control
Last updated Jul 10, 2026 00:00 UTC
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Targeted drug shows promise for rare vulvar cancer
Disease control Not yet recruitingThis phase 2 trial tests a drug called tisotumab vedotin in people with advanced squamous cell carcinoma of the vulva that has returned or spread. The drug is an antibody-drug conjugate designed to seek out and destroy cancer cells. The study aims to see how many participants' tu…
Phase 2 • Sponsor: GOG Foundation • Aim: Disease control
Last updated Jul 01, 2026 00:00 UTC
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Genetically modified cells injected into mouth lesions to stop cancer before it starts
Disease control Not yet recruitingThis early-phase trial tests whether specially engineered immune cells (NK cells) can safely treat high-risk precancerous spots in the mouth. The cells are injected directly into the lesions and are designed to target a protein called TROP2, while also resisting signals that norm…
Phase 1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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New chemo cocktail aims to tame advanced head and neck cancer
Disease control Not yet recruitingThis phase 2 trial tests whether a combination of two chemotherapy drugs, cyclophosphamide and etoposide, can control advanced head and neck cancer in adults who have already tried standard treatment. 120 participants will receive either the drug combo or methotrexate for 6 month…
Phase 2 • Sponsor: National Cancer Institute, Egypt • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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New drug duo aims to shrink tough head and neck tumors
Disease control Not yet recruitingThis study tests whether adding fianlimab to the standard cemiplimab plus chemotherapy can better shrink tumors in adults with advanced HPV-positive head and neck cancer. About 90 participants will receive either the two-drug or three-drug combination before radiation. The goal i…
Phase 2 • Sponsor: University of Chicago • Aim: Disease control
Last updated Jun 27, 2026 08:12 UTC
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Glowing cancer cells: a new way to see tumors during surgery?
Diagnosis Not yet recruitingThis trial tests whether two imaging agents, Panitumumab-IRDye800 and [18F]NOTA-ABY-030, are safe and useful for helping surgeons identify head and neck tumors and cancer-containing lymph nodes during surgery. Adults with head and neck squamous cell carcinoma who are scheduled fo…
Phase 1 • Sponsor: Vanderbilt-Ingram Cancer Center • Aim: Diagnosis
Last updated Aug 05, 2026 00:00 UTC
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AI-Powered endoscopy aims to spot head and neck cancer earlier
Diagnosis Not yet recruitingThis study will test artificial intelligence algorithms that analyze video from routine endoscopies of the head and neck. The AI will try to detect, classify (benign vs. malignant), and outline lesions, comparing its performance to doctors and lab results. About 283 adults with s…
Sponsor: Istituto Italiano di Tecnologia • Aim: Diagnosis
Last updated Jun 27, 2026 12:35 UTC
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Veterans test daily cream to stop face skin cancers
Prevention Not yet recruitingThis Phase 3 trial tests whether a daily imiquimod cream applied to the face for 12 weeks can prevent new basal cell carcinomas (BCC) in 1,630 veterans at high risk. Participants apply either the active cream or a placebo and are followed for up to 3 years with skin exams. The go…
Phase 3 • Sponsor: VA Office of Research and Development • Aim: Prevention
Last updated Aug 23, 2026 00:00 UTC
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Scalp cancer surgery that leaves hair follicles behind
Symptom relief Not yet recruitingResearchers are testing a modified surgical technique for squamous cell carcinoma in situ on the scalp, an early form of skin cancer. Standard surgery can remove deep tissue that holds hair follicles, causing permanent bald spots. This pilot study uses partial thickness excision,…
Sponsor: The Cooper Health System • Aim: Symptom relief
Last updated Sep 11, 2026 00:00 UTC
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Botox before the knife: could a Pre-Surgery injection lead to Better-Looking scars?
Symptom relief Not yet recruitingThis trial tests whether injecting Botox (abobotulinumtoxin-A) into the forehead muscles just before paramedian forehead flap surgery can improve the cosmetic appearance of the resulting scar. Adults with nasal skin cancer defects needing this reconstruction are randomly assigned…
Phase 4 • Sponsor: Vanderbilt University Medical Center • Aim: Symptom relief
Last updated Aug 28, 2026 00:00 UTC
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Which Pre-Surgery combo extends life in esophageal cancer? a virtual trial seeks answers
Knowledge-focused Not yet recruitingThis study compares two standard pre-surgery treatments for a common type of esophageal cancer: chemoradiotherapy (radiation plus chemo) versus immunochemotherapy (immunotherapy plus chemo). Using data from 400 patients' medical records, researchers will analyze which approach is…
Sponsor: Henan Cancer Hospital • Aim: Knowledge-focused
Last updated Aug 23, 2026 00:00 UTC
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Can a glowing drug light up head and neck tumors?
Knowledge-focused Not yet recruitingThis early-phase trial is testing whether injecting a fluorescently labeled version of the immunotherapy drug nivolumab directly into head and neck tumors is safe and helps visualize the tumor and nearby lymph nodes during surgery. Adults with head and neck squamous cell carcinom…
Early phase 1 • Sponsor: Vanderbilt-Ingram Cancer Center • Aim: Knowledge-focused
Last updated Aug 05, 2026 00:00 UTC
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New study aims to read skin cancer depth from photos
Knowledge-focused Not yet recruitingThis study looks back at 238 patients with a common skin cancer called squamous cell carcinoma. Researchers will compare special skin photos (dermoscopic images) with lab results from removed tumors. The goal is to see if certain features in the photos can tell how deep the cance…
Sponsor: Istanbul Training and Research Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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New ultrasound technique aims to improve skin cancer surgery outcomes
Knowledge-focused Not yet recruitingThis study looks at whether using a high-frequency ultrasound before surgery for common skin cancers on the head and neck can help surgeons remove the entire tumor the first time. About 400 adults with basal or squamous cell skin cancer will be in the study. Some will get the sta…
Sponsor: Państwowy Instytut Medyczny Ministerstwa Spraw Wewnętrznych i Administracji • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:13 UTC