Spondyloarthropathy

This study looks at whether people with a type of spinal arthritis (non-radiographic axial spondyloarthritis) who are in remission need to keep taking secukinumab to avoid flare-ups. About 240 adults with confirmed inflammation will either continue the drug or switch to a placebo…

This study tests whether a short, standardized 4-minute heart-healthy talk is as effective as a full 60-minute personalized session with a dietitian for lowering LDL cholesterol and improving diet. Participants are adults aged 30–80 with rheumatoid arthritis, psoriatic arthritis,…

This Phase 2 study tests an experimental drug called SPY002-072 in 285 adults with moderately to severely active rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis. Participants receive either the drug or a placebo, and researchers measure changes in disease ac…

This study looks at how well upadacitinib (RINVOQ) works for people with axial spondyloarthritis, a type of inflammatory arthritis that causes chronic back pain. About 338 adults in Germany will take the drug as prescribed by their doctor and be followed for 52 weeks. Researchers…

This phase 3 trial tests whether the drug filgotinib, taken as a daily pill, can reduce symptoms of active axial spondyloarthritis—a type of arthritis that causes back pain and stiffness. About 495 adults with the condition will receive either filgotinib (200 mg or 100 mg) or a p…

This phase 3 trial tests whether starting a strong TNF inhibitor (golimumab) early in peripheral spondyloarthritis can help patients reach drug-free remission, compared to the usual step-up approach with milder drugs. 90 adults with recent-onset disease will be randomly assigned …

This study is testing whether a simpler, less expensive treadmill test can accurately measure cardiorespiratory fitness in people with spondylarthritis, a chronic inflammatory joint disease. The simpler test will be compared against the gold standard, which uses direct gas exchan…

This study tests the Shingrix vaccine in over 2,000 adults with autoimmune rheumatic diseases like rheumatoid arthritis and lupus, who are at higher risk for shingles. Researchers will compare vaccinated patients to unvaccinated ones to see if the vaccine is safe and triggers a s…

People with rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis often struggle to stay in work. This trial tests a 6-month vocational rehabilitation program called WORK-ON, which includes a coordinating occupational therapist, group sessions with peers, and ind…

This trial tests a six-month program where a coordinating rheumatology nurse helps people with inflammatory arthritis set goals and plan actions to manage their condition. Participants also get access to physiotherapy, occupational therapy, and social work support as needed. The …

This study tests whether a home-based exercise program guided by online videos can improve symptoms and quality of life in people with axial spondyloarthritis, a type of arthritis affecting the spine. Participants follow video exercises for 3 months, and researchers compare their…

This study tests an online program designed to help people with inflammatory arthritis remain employed. The program includes eLearning modules, group video sessions, and consultations with an occupational therapist and vocational counselor. About 528 participants from three Canad…

This study looks at whether adding acupuncture to usual care can reduce spinal pain in people with axial spondyloarthritis who did not get relief from NSAIDs. About 140 adults in Singapore will either receive standard rheumatology care or standard care plus acupuncture. The main …

This study aims to improve how doctors diagnose and treat chronic muscle and joint pain by using simple questionnaires and pain sensitivity tests. Researchers will study 250 adults with conditions like osteoarthritis, fibromyalgia, chronic low back pain, or inflammatory arthritis…

This study investigates how people with axial spondyloarthritis (axSpA) experience sudden worsening of symptoms, known as flares. Over 12 months, 40 participants use a digital diary to track symptoms, diet, lifestyle, and self-management strategies, and provide blood samples duri…

This study was designed to track pregnancies in women with rare autoimmune and systemic diseases to understand complications and improve care. It planned to enroll women with conditions like lupus, rheumatoid arthritis, and scleroderma. However, the study was withdrawn before any…

This study is a large registry that will follow 5,000 people with psoriatic arthritis or spondyloarthritis across North America. Researchers will collect information on how different approved treatments work and their side effects over time. The goal is to better understand these…

This study is building a large collection of blood samples from 3,000 people with rheumatoid arthritis. Researchers will use these samples to look for biomarkers that could help predict disease activity or treatment side effects. Participants must already be in a registry and sta…

This study looks at whether helping people with inflammatory arthritis address social needs—like food, housing, or transportation—can reduce missed doctor visits. About 100 adults with conditions like rheumatoid arthritis or lupus who have missed appointments in the past year wil…

This study follows 250 people with long-term back pain who may have early axial spondyloarthritis, a type of inflammatory arthritis. Researchers want to learn how the disease develops and whether a 6-month rehab program with a physiotherapist can help. The goal is to reduce the y…