Spasmodic dystonia

This study uses botulinum toxin (Botox) injections to treat movement disorders such as dystonia, tremor, and spasticity. Up to 2,000 participants aged 2 and older will receive tailored injections, with doctors trained in proper techniques. The goal is to manage symptoms and build…

This study tests whether a wearable device that gives real-time feedback on voice use can help people with voice disorders (like vocal nodules or muscle tension dysphonia) improve their voicing habits outside the clinic. Participants wear a small sensor on their neck that tracks …

This trial investigates whether deep brain stimulation (DBS) can help people with a rare voice disorder called adductor laryngeal dystonia, which causes strained or broken speech. Participants will undergo DBS surgery as part of their care, and researchers will study brain signal…

This study is testing a computer program called DystoniaNet that uses artificial intelligence to help doctors diagnose isolated dystonia, a movement disorder. The trial will enroll 1000 people with dystonia or other conditions that look like it, such as Parkinson's disease or ess…

Laryngeal dystonia causes the vocal folds to spasm, leading to a strained or breathy voice. This study tests whether a non-invasive brain stimulation technique called rTMS can calm the overactive brain signals that cause these spasms. Twenty-five adults with laryngeal dystonia wi…

This early study tests whether a non-invasive brain stimulation technique called tDCS can improve voice quality in people with laryngeal dystonia (spasmodic dysphonia). Ten participants will receive active, sham, and no stimulation to compare effects. The goal is to see if target…

This study tests a brain-computer interface (BCI) that gives real-time feedback to help people with laryngeal dystonia control voice spasms. About 40 adults with a specific type of voice disorder will try this adaptive neurofeedback therapy. The goal is to reduce the number of vo…

This study looks at whether the method of delivering voice therapy affects how well people with voice problems (like muscle tension dysphonia or vocal cord lesions) can communicate over a year. About 120 adults who do not smoke and have not had voice therapy or surgery recently w…

This study will use smartphone recordings of speech, eye movements, and arm fatigue to measure key symptoms of myasthenia gravis, a condition that causes muscle weakness. Researchers will compare 225 participants (both with and without MG) to see if machine learning can accuratel…

This study tests whether using a new classification system (RTSS-Voice) to document voice therapy sessions helps people with muscle tension dysphonia, a condition causing hoarseness and vocal strain. Researchers will compare outcomes from clinicians' first year using the system t…

This study looks at how a gentle vibration applied to the throat affects brain activity and voice in people with laryngeal dystonia, a condition that causes involuntary voice spasms. Researchers will use brain scans and voice recordings to understand why some people get relief fr…

This study uses brain scans and genetic tests to explore why different forms of focal dystonia develop. Researchers will compare brain activity and structure in people with dystonia, their unaffected relatives, and healthy volunteers. The goal is to identify unique brain markers …

This study looks at how deep brain stimulation (DBS) — a treatment already used for movement disorders — affects voice and speech in people with laryngeal dystonia or voice tremor. Researchers will record brain signals during surgery and measure voice changes afterward. The goal …

Researchers at Massachusetts Eye and Ear are studying 165 people with laryngeal dystonia or voice tremor, along with healthy volunteers, to better understand these voice disorders. Participants will undergo voice recordings, breathing tests, and imaging to identify distinct featu…

This study looks at how brain changes and genetic risk factors are linked in laryngeal dystonia, a voice disorder. Researchers will use brain imaging and DNA tests in up to 410 people, including patients, their relatives, and those with similar voice problems. The goal is to find…

This study uses brain scans (fMRI, MEG, EEG) and a numbing throat spray to understand what goes wrong in the brains of people with laryngeal dystonia or voice tremor. Researchers will compare brain activity between these groups and healthy volunteers. The goal is to find unique b…