Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Brain scans and DNA may unlock secrets of voice disorder

NCT ID NCT03042975

Knowledge-focused Sponsor: Kristina Simonyan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how brain changes and genetic risk factors are linked in laryngeal dystonia, a voice disorder. Researchers will use brain imaging and DNA tests in up to 410 people, including patients, their relatives, and those with similar voice problems. The goal is to find markers that could lead to better detection, diagnosis, and risk assessment for family members.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 410 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2017

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

laryngeal dystonia unaffected relatives of laryngeal dystonia patients voice tremor muscle tension dysphonia

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: 1. Males and females of diverse racial and ethnic background, with age across the lifespan; 2. Laryngeal Dystonia patients * phenotype: adductor or abductor * genotype: familial or sporadic 3. Voice Tremor patients * essential or * dystonic 4. Muscle tension dysphonia patients 5. Unaffected relatives of laryngeal dystonia patients with * familial laryngeal dystonia * early-onset laryngeal dystonia (onset at ≤ 35 y.o.) * typical onset laryngeal dystonia (onset at ≥ 40 y.o.) 6. Native English speakers. 7. Right-handedness. 8. Normal cognitive status. Exclusion criteria: 1. Subjects who are incapable of giving informed consent. 2. Pregnant or breastfeeding women until a time when they are no longer pregnant or breastfeeding. 3. Subjects with past or present medical history of (a) major neurological problems, such as stroke, movement disorders (other than LD and VT in the patient groups), brain tumors, traumatic brain injury with loss of consciousness, ataxias, myopathies, myasthenia gravis, demyelinating diseases, alcoholism, drug dependence; (b) psychiatric problems, such as schizophrenia, bipolar depression, obsessive-compulsive disorder; (c) laryn¬geal problems, such as vocal fold paralysis, paresis, vocal fold nodules and polyps, carcinoma, chronic laryngitis. 4. Patients who are not symptomatic due to treatment with botulinum toxin injections into the laryngeal muscles. 5. Subjects who receive medication(s) affecting the central nervous system. 6. Subjects with a history of major brain and/or laryngeal surgery. 7. Subjects who have tattoos, ferromagnetic objects in their bodies that cannot be removed for imaging study participation.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Laryngeal dystonia are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

Dystonia spasmodic dystonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Laryngeal dystonia Muscle tension dysphonia Unaffected relatives of laryngeal dystonia patients Voice tremor

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Massachusetts Eye and Ear Infirmary

    RECRUITING

    Boston, Massachusetts, 02114, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.