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Can brain stimulation restore a steady voice?

NCT ID NCT05506085

Disease control Sponsor: Indiana University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This trial investigates whether deep brain stimulation (DBS) can help people with a rare voice disorder called adductor laryngeal dystonia, which causes strained or broken speech. Participants will undergo DBS surgery as part of their care, and researchers will study brain signals, vocal cord movements, and voice recordings before and after the device is activated. The goal is to understand how faulty brain patterns contribute to the condition and to see if DBS improves voice function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Deep brain stimulation of the globus pallidus interna
What this could lead to
If successful, this could refine DBS as a treatment for laryngeal dystonia, potentially improving voice and quality of life for those with this rare condition.
What could go wrong
This is a small, early-stage study (12 participants) focused on understanding mechanisms, not a proven treatment. DBS surgery carries risks like infection or bleeding, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 12 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2022

Expected to finish

Aug 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Individuals presenting for routine neurology clinic appointments will be screened for clinical DBS (Deep brain stimulation) candidacy

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with ADLD and ADLD plus tremor, as diagnosed by routine clinical examination by laryngologist, speech language pathologist, and neurologist. * Patients undergoing globus pallidus interna (GPi) deep brain stimulation (DBS) for ADLD with tremor * Age range of 18-80 years * Native speakers of American English will be recruited since there are known differences in voice and neural signals of native and non-native speakers * No evidence for dementia as assessed by neurologist. * No evidence for severe untreated mood disorder as assessed by neurologist, or as evident on self-report (Beck Depression Inventory-II score \> 29, Beck Anxiety Inventory Score \> 26. * At least 3 months since last botulinum toxin injection and the patients would need to be fully symptomatic with no residual effects of botulinum toxin on voice quality. Exclusion Criteria: * Individuals younger than 18 years and older than 80 years of age. * Women who plan to become pregnant during the study period or are currently breastfeeding. * Prior history of stroke, brain surgery, or other neurological disorder besides the one under study. * Prior laryngeal framework surgeries or other disorders affecting the vocal folds * Patients who are asymptomatic due to treatment with botulinum toxin into the vocal folds. * Presence of ferromagnetic implants and cardiac implants that would be contraindicated to MRI * Gagging or discomfort that would preclude the placement of the endoscope to visualize the larynx * Dementia, severe depression or severe anxiety. * Any clinical condition or medication judged by the investigators to potentially preclude the patient from safely completing awake brain surgery and research protocols.

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Conditions

The condition(s) this trial relates to.

spasmodic dystonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adductor spastic dysphonia of dystonia Laryngeal dystonia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Indiana University

    RECRUITING

    Indianapolis, Indiana, 46202, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.