Please sign in to follow a disease.
Severe pre-eclampsia
MONDO:0001641Preeclampsia with a systolic blood pressure of 160 mmHg or higher, or a diastolic blood pressure of 110 mmHg or higher on two occasions at least 4 hours apart while on bedrest. It is associated with thrombocytopenia (platelets less than 100,000 per microliter), impaired liver function (twice normal elevation of hepatic transaminases; severe, persistent right upper quadrant or epigastric pain), progressive renal insufficiency (serum creatinine greater than 1.1 mg/dL or doubling of baseline in the absence of other renal disease), pulmonary edema, or new-onset cerebral or visual disturbances.
Also known as: Preeclampsia with severe features, severe preeclampsia
59 clinical trials for this condition and its sub-types, 27 tagged with Severe pre-eclampsia itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Part of
Sub-types of Severe pre-eclampsia
-
HELLP syndrome 13 trials
-
Which IV drug tames severe preeclampsia better? labetalol vs hydralazine
Disease control CompletedThis completed study compared two intravenous blood pressure medications, labetalol and hydralazine, in 132 pregnant women with severe preeclampsia. The goal was to see which drug more effectively lowered blood pressure to safe levels. Results could help doctors in the local sett…
Sponsor: Muhammad Aamir Latif • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
-
Which blood pressure drug better protects kidneys in severe pre-eclampsia?
Disease control CompletedThis study looked at 170 women with severe pre-eclampsia in the ICU to see which blood pressure drug—phentolamine or glyceryl trinitrate (GTN)—better protects kidney function. Pre-eclampsia can harm the kidneys, and GTN has been linked to kidney injury in some cases. The research…
Phase 4 • Sponsor: Assiut University • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
-
Simple ultrasound test may spot kidney risk in preeclampsia patients
Diagnosis CompletedThis study tested whether a special ultrasound score (called VEXUS) can predict acute kidney injury in women with severe preeclampsia when they are admitted to the hospital. Researchers examined 70 women using Doppler ultrasound to check blood flow in key veins. The goal was to s…
Sponsor: Cairo University • Aim: Diagnosis
Last updated Jun 27, 2026 13:00 UTC
-
New study: common painkillers may be safe for new moms with severe preeclampsia
Symptom relief CompletedThis study looked at whether adding nonsteroidal anti-inflammatory drugs (NSAIDs) to standard pain relief is safe for women with severe preeclampsia after giving birth. 287 women participated, and researchers measured their blood pressure and need for blood pressure medication. T…
Phase 2 • Sponsor: Washington University School of Medicine • Aim: Symptom relief
Last updated Jun 27, 2026 14:01 UTC
-
Could a simple blood test predict severe preeclampsia?
Knowledge-focused CompletedThis study looks at whether a blood gas measurement called base excess differs between pregnant women with severe preeclampsia and those with normal blood pressure. Researchers will test 100 women before delivery to see if abnormal base excess levels are linked to more severe dis…
Sponsor: Saint Thomas Hospital, Panama • Aim: Knowledge-focused
Last updated Jul 18, 2026 00:00 UTC
-
Preeclampsia may weaken the heart during pregnancy, new study finds
Knowledge-focused CompletedThis study examined how well the heart relaxes between beats in 80 pregnant women—40 with preeclampsia and 40 healthy. Researchers used ultrasound to measure heart function. The goal was to see if preeclampsia is linked to early signs of heart strain, which could help doctors cat…
Sponsor: University Tunis El Manar • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC