Severe combined immunodeficiency
MONDO:0015974Severe combined immunodeficiency (SCID) comprises a group of rare monogenic primary immunodeficiency disorders characterized by a lack of functional peripheral T lymphocytes resulting in early-onset severe respiratory infections and failure to thrive. They are classified according to immunological phenotype into SCID with absence of T cells but presence of B cells (T-B+ SCID) or SCID with absence of both (T-B- SCID). Both of these groups include several forms, with or without natural killer (NK) cells.
Also known as: SCID, severe combined immunodeficiency, severe combined immunodeficiency (disease), severe combined immunodeficiency disease
38 clinical trials for this condition and its sub-types, 24 tagged with Severe combined immunodeficiency itself.
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Sub-types of Severe combined immunodeficiency
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Familial severe combined immunodeficiency 0 trials · 22 incl. sub-types
14 sub-types
- T-B+ severe combined immunodeficiency due to gamma chain deficiency 10 trials
- Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency 6 trials
- Omenn syndrome 4 trials
- Severe combined immunodeficiency due to DCLRE1C deficiency 3 trials
- T-B+ severe combined immunodeficiency due to JAK3 deficiency 2 trials
- Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive 2 trials
- MHC class II deficiency 1 trial Sub-types →
- Reticular dysgenesis 1 trial Sub-types →
- Cernunnos-XLF deficiency 0 trials
- Immunodeficiency 104 0 trials
- Immunodeficiency 105 0 trials
- Immunodeficiency 18 0 trials
- Immunodeficiency 19 0 trials
- Immunodeficiency 49 0 trials
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T-B- severe combined immunodeficiency 0 trials · 14 incl. sub-types
16 sub-types
- Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency 6 trials
- Omenn syndrome 4 trials
- Severe combined immunodeficiency due to DCLRE1C deficiency 3 trials
- Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-positive 2 trials
- DNA ligase IV deficiency 1 trial
- Reticular dysgenesis 1 trial Sub-types →
- Cernunnos-XLF deficiency 0 trials
- Combined immunodeficiency due to partial RAG1 deficiency 0 trials
- Combined immunodeficiency with skin granulomas 0 trials
- Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia 0 trials
- Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia 0 trials
- Neutrophil immunodeficiency syndrome 0 trials
- Reticular dysgenesis-like severe combined immunodeficiency 0 trials
- Severe combined immunodeficiency due to DNA-PKcs deficiency 0 trials
- Severe combined immunodeficiency due to LCK deficiency 0 trials
- Short-limb skeletal dysplasia with severe combined immunodeficiency 0 trials
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T-B+ severe combined immunodeficiency 0 trials · 10 incl. sub-types
10 sub-types
- T-B+ severe combined immunodeficiency due to gamma chain deficiency 10 trials
- T-B+ severe combined immunodeficiency due to JAK3 deficiency 2 trials
- T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency 1 trial
- T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta 0 trials Sub-types →
- T-B+ severe combined immunodeficiency due to CD45 deficiency 0 trials
- Combined immunodeficiency, X-linked 0 trials
- Immunodeficiency 104 0 trials
- Lung fibrosis-immunodeficiency-46,XX gonadal dysgenesis syndrome 0 trials
- Severe combined immunodeficiency due to CORO1A deficiency 0 trials
- Severe combined immunodeficiency due to LAT deficiency 0 trials
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2 sub-types
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Immunodeficiency 79 0 trials
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Janus kinase-3 deficiency 0 trials
Most studied deeper sub-types
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Bubble boy disease gene therapy trial launches
Disease control Not yet recruitingThis trial tests a gene therapy given by IV for X-linked severe combined immunodeficiency (SCID-X1), a rare immune disorder. Ten participants with no matched donor will receive a lentiviral vector to correct the genetic defect. The goal is to restore immune function and improve s…
Phase 1/2 • Sponsor: Shenzhen Geno-Immune Medical Institute • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
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One-Time gene fix could rescue 'Bubble Boy' disease
Disease control Not yet recruitingThis study tests a gene therapy given by IV for ADA-SCID, a rare and life-threatening immune disorder. The treatment uses a modified virus to deliver a working gene, aiming to restore the immune system. Ten participants will be monitored for safety and immune recovery over one ye…
Sponsor: Shenzhen Geno-Immune Medical Institute • Aim: Disease control
Last updated Aug 28, 2026 00:00 UTC
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Can umbilical cord stem cells help repair spinal cord injuries?
Disease control Not yet recruitingThis trial is testing whether a single injection of stem cells from umbilical cord tissue, given into the spinal fluid, is safe and tolerable for people who have had a traumatic spinal cord injury within the past ten years. The study will monitor participants for side effects and…
Early phase 1 • Sponsor: Cell Therapy LLC • Aim: Disease control
Last updated Aug 02, 2026 00:00 UTC
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Newborn SCID screening study aims to unlock secrets of immune disorders
Knowledge-focused Not yet recruitingThis study follows infants who had a positive newborn screening test for severe combined immunodeficiency (SCID), a group of genetic disorders that leave babies vulnerable to life-threatening infections. Researchers will track these children to identify the underlying causes of t…
Sponsor: Nantes University Hospital • Aim: Knowledge-focused
Last updated Jul 17, 2026 00:00 UTC